[IMPORTANT: The user has invoked the "paper-recommender" skill, indicating they want you to follow its instructions. The full skill content is loaded below.]
---
name: paper-recommender
description: "每日定时推送高质量论文推荐 — PubMed检索 → Hermes+Claude双重评估 → 仅推最优1篇 → HTML深度解读"
version: 2.4.0
author: Hermes
tags: [PubMed, 论文推荐, Claude评估, 文献解读, 科研]
---
# 📚 每日论文推荐工作流 (Paper Recommender)
## 职责
根据用户的6个研究兴趣方向，每日定时从PubMed检索近期高质量论文，经过Hermes+Claude双重评估后，**只选最优的1篇**，下载PDF+提取原图，制作公众号风格的HTML深度解读文件并推送。
## 用户研究方向
1. 帕金森病(PD) / GZR18 / α-synuclein
2. 神经炎症 / 小胶质细胞 / 星形胶质细胞
3. 细胞死亡方式 (Mitoxyperiosis / 铁死亡 / 焦亡 / 泛素化降解)
4. 外泌体 / 细胞外囊泡 / 神经退行性疾病
5. 脑缺血 / 脑卒中 / 神经保护
6. 生信分析 / 单细胞测序 / 多组学
## ⚡ 用户核心课题（跨所有方向的超优先主题）
**博一课题**：Warburg乳酸 → PCAF介导RhoA K118/K162乳酸化 → RhoA持续激活 → 线粒体远离质膜 → 拮抗mitoxyperiosis
所有方向的论文推荐，只要与以下关键词相关的论文**自动获得更高优先级**，应优先于同评分不相关的论文推送：
- Mitoxyperiosis / 线粒体-质膜接触 / 新型细胞死亡
- 乳酸化修饰(Kla) / PCAF / p300 / 组蛋白乳酸化
- RhoA信号 / 细胞骨架重排 / 小G蛋白修饰
- Warburg效应 / 肿瘤代谢 / LDHA抑制
- 糖酵解 / 乳酸代谢 / 肿瘤免疫代谢
- 禁食疗法 / 卡路里限制 / 联合免疫治疗
- 代谢组学 / 能量代谢 / 肿瘤微环境
评估论文时，额外增加一个维度：**"课题借鉴价值"** — 这篇论文中有什么技术、概念、实验设计可以直接复用到用户的mitoxyperiosis-乳酸化课题？
## 定时推送安排
| 时间 | 主题 | 关键词 |
|:----:|------|--------|
| 08:00 | PD/帕金森病 | Parkinson's disease, α-synuclein, MPTP, dopamine neuron |
| 11:00 | 神经炎症/胶质细胞 | neuroinflammation, microglia, astrocyte, NLRP3 |
| 13:00 | 细胞死亡/信号通路 | cell death, mitoxyperiosis, ferroptosis, ubiquitination |
| 15:00 | 外泌体/细胞通讯 | exosome, extracellular vesicle, neural, brain |
| 17:00 | 脑缺血/神经保护 | cerebral ischemia, stroke, neuroprotection, MCAO |
| 19:00 | 生信/前沿技术 | single-cell, multi-omics, bioinformatics, spatial transcriptomics |
## ⚠️ 已知工具陷阱
### 文件系统隔离（重要！）
`execute_code` 运行在沙箱环境中，**不能直接访问** `terminal` 工具写入 `/tmp/` 或 `$HOME/` 的文件。反之亦然。
- ❌ 错误做法：terminal写入`/tmp/fig1_b64.txt`，然后用execute_code的`open()`读取 → 文件不存在
- ✅ 正确做法1：所有数据处理在terminal中完成（Python脚本通过`python script.py`执行）
- ✅ 正确做法2：将数据处理写成`.py`文件写入磁盘，再用terminal(`python path/to/script.py`)执行
### 大文件HTML生成
当HTML嵌入base64图片时（5张Nature原图 ≈ 4MB），`write_file`会因大小限制失败。
- ❌ 不要直接用write_file写4MB+的HTML
- ✅ 策略：写一个Python builder脚本到磁盘（`write_file → build_html.py`），然后`terminal("python build_html.py")`执行它
### Claude CLI 长提示词超时陷阱
claude -p 传入大段文本时容易超时（exit code 124，返回空），特别是在Windows git-bash环境。
- ❌ 一次性传入4篇论文的完整摘要+评估指令 → 超时
- ✅ 策略1：将评估指令简化，每篇论文控制到1-3句关键信息；或拆分为多次调用分别评估单篇
- ✅ 策略2：用 `head -N` 或 `tail -N` 截断输出（如 `claude -p "评估..." 2>&1 | head -60`），防止Claude生成过长内容导致超时。即使Claude内部未完成，前60行通常已包含评分结果
### Cell Press PII清理模式（重要！）
PubMed esummary返回的PII含括号和连字符（如 `S0896-6273(26)00386-7`），CDN URL需要去掉这些字符：
- ❌ `tr -d '()'` → 只去除括号，留下连字符 → CDN返回404
- ✅ `tr -d '()-'` → 同时去除括号和连字符 → CDN返回200
- 详见 `references/figure-download-patterns.md` 中的修正实例
### Python f-string与JavaScript花括号冲突（HTML Builder陷阱）
当用Python f-string构建HTML时，JavaScript代码中的`{}`（如`canvas.width`、`img.onload = function() { }`、`loadImage("fig1", fig1_b64)`）会被Python误解析为f-string占位符，导致SyntaxError。
- ❌ `html = f'''...<script>img.onload = function() { canvas.width = 780; }</script>...'''` → SyntaxError
- ✅ 策略1：用字符串列表拼接代替f-string（将HTML拆分为多个部分append到列表，用`+`或`''.join()`组合）
- ✅ 策略2：将HTML结构和JS作为独立字符串，用`.replace()`注入base64数据
- ✅ 策略3：在JS中所有`{`和`}`都必须加倍成`{{`和`}}`（仅在必须用f-string时）
- 推荐策略：使用函数`build_html(fig_b64, ...)`接受字典参数，返回拼接好的字符串（详见Step 6 HTML模板）
### Windows Python路径陷阱
在 Windows git-bash 中，Python 脚本不识别 MSYS 路径格式（`/c/Users/...`）：
- ❌ `open("/c/Users/forgase/fig1_b64.txt")` → FileNotFoundError
- ✅ `open("C:/Users/forgase/fig1_b64.txt")` — 正斜杠在 Windows Python 中可识别
- 同理，`python3` 命令在 Windows 上可能被应用执行别名拦截 → 始终使用 `python`
## 执行流程（完整版）
### Step 1: PubMed检索 — 两阶段策略
**执行位置：terminal 而非 execute_code**
PubMed API调用应在 `terminal` 中通过 `python -c "..."` 或写脚本后执行。`terminal` 中的 Python 连接更稳定，且结果可被后续terminal命令使用（写入文件、管道传递）。避免在 `execute_code` 中做PubMed检索——沙箱环境的网络连接可能不稳定，且JSON结果无法跨沙箱传递给terminal。
**日期范围两种方式（方式B更可靠）**：
```python
# 方式A: mindate/maxdate 参数（有时返回0结果，不可靠）
params = {
'db': 'pubmed', 'term': query,
'mindate': '<3个月前>', 'maxdate': '<今天>',
'datetype': 'pdat', 'retmax': 15, 'retmode': 'json'
}
# 方式B: [dp] 查询语法（推荐，已验证可靠）
query = '(ferroptosis[Title/Abstract] OR ...) AND ("2026/03/01"[dp] : "2026/06/12"[dp])'
params = {
'db': 'pubmed', 'term': query,
'retmax': 15, 'retmode': 'json'
}
```
`dp` (Date - Publication) 语法格式：`"YYYY/MM/DD"[dp] : "YYYY/MM/DD"[dp]`。日期之间需要空格+冒号+空格。此方式不受 `mindate/maxdate` 参数兼容性问题影响。
详见 `references/pubmed-API-patterns.md` 第4节。
**阶段A — 主题搜索**：用关键词搜该方向近期论文
**阶段B — 高IF期刊过滤**：用主题词 + `("Nature"[Journal] OR "Cell"[Journal] OR ...)` 格式搜
⚠️ 关键陷阱：
- `sort=date` 被PubMed忽略（返回warning），不要用
- 期刊名必须用 `"全称"[Journal]` 格式，裸词会被翻译为MeSH词条
- 复杂查询在curl中容易URL编码失败，优先用Python
- PubMed JSON返回的ID列表键名为小写 `idlist`，不是 `IdList`（驼峰）
### Step 2: 获取论文详情并初筛
```python
import urllib.request, json, time
# 获取元数据
url = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&id=<PMIDs>&retmode=json'
# 获取摘要
url = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=<PMIDs>&retmode=xml'
```
**初筛硬性门槛**（必须同时满足）：
1. IF > 10 或领域顶刊
2. 2026年3月后发表
3. 与用户研究方向直接相关
4. 原创研究（pubtype不含Review）
5. 非 News & Views / Letter / 编辑评论
6. **有作者（推荐用 efetch XML 确认，而非 esummary 的 hascreator 字段）**
- `esummary`的`hascreator`字段有时不可靠：已验证所有高IF期刊论文均返回`hascreator='N'`（即使是多作者原创研究）。
- 改用 efetch XML：统计`<Author>`标签数（`len(re.findall(r'<Author>', xml_text))`），大于0即有作者。
- 若只能用 esummary：不要仅因`hascreator='N'`排除——结合`pubtype`和`HasAbstract`综合判断。
### Step 3: Claude Code深度评估（Hermes + Claude 双重评判）
将经过初筛的候选论文交给 Claude Code 严格评估：
```
claude -p "严格评估以下论文，从5个维度各评1-10分..."
```
**5维度评分**：
1. **逻辑完整性** (1-10)：完整正反验证（gain+loss of function）、KO/KI模型
2. **方法学水平** (1-10)：前沿技术（单细胞测序、冷冻电镜、活细胞成像、TurboID等）
3. **创新性** (1-10)：新概念/新机制/新方法，首次报道
4. **可借鉴性** (1-10)：实验设计是否值得用户在自己的课题中参考 **← 这是最关键的维度**
5. **临床转化潜力** (1-10)：体内验证或治疗意义
### Step 4: 唯一推荐（核心规则）
- Claude评分 < 30分（平均<6分）或任何单维度 < 5分 → **不推荐**，跳过
- 多个候选都达标 → **只选最优的1篇**，不要让用户选
- Hermes再次确认质量 + 相关性 + 可借鉴性 → 只有双方都确认才通过
- **如果这篇研究方向不匹配（如planarian flatworm研究），即使评分高也不能推**
### Step 5: 下载PDF + 提取Figure图片
**PDF下载**：
- Nature系列: `https://www.nature.com/articles/{article_id}.pdf`（已验证：Nature, Nat Neurosci, Nat Med, Nat Commun均可下载）
- Cell Press/Elsevier: PDF有ScienceDirect防护，通常无法通过curl下载
- 所有期刊的Figure图片可通过CDN下载（详见`references/figure-download-patterns.md`）
- 注意：部分期刊有付费墙，PDF可能无法下载，此时跳过PDF但继续下载Figure图片
### Nature系列PDF下载注意
- Nature系列: `https://www.nature.com/articles/{article_id}.pdf`（已验证：Nature, Nat Neurosci, Nat Med可下载真实PDF）
- **Nat Commun PDF可能为HTML**：`file`命令检查下载文件，若为"HTML document"则非真实PDF（反爬重定向）。不影响Figure图片下载（CDN独立于PDF）。
- Cell Press/Elsevier: PDF有ScienceDirect防护，通常无法通过curl下载
**Figure提取（Nature系列通用模式 — 已验证 Nature, Nat Neurosci, Nat Med, Nat Commun）**：
```bash
# 1. 从HTML中提取所有figure图片URL（通用模式，匹配所有s415XX系列期刊）
curl -s -L -H "User-Agent: Mozilla/5.0" "https://www.nature.com/articles/{article_id}" \
| grep -oP 'https://media\.springernature\.com/[^"'"'"'<>]+s415\d\d[^"'"'"'<>]*\.(?:png|jpg|webp)' \
| sort -u
# 2. 暴力枚举法（推荐，因为url模式固定—不依赖HTML解析）
for fig in 1 2 3 4 5 6 7; do
url="https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F${ARTICLE_ID}/MediaObjects/${JOURNAL_ID}_${YEAR}_${ARTICLE_NUM}_Fig${fig}_HTML.png"
code=$(curl -s -o /dev/null -w "%{http_code}" -L "$url" -H "User-Agent: Mozilla/5.0")
if [ "$code" != "404" ]; then
curl -s -L "$url" -H "User-Agent: Mozilla/5.0" | base64 -w 0 > "/c/Users/forgase/fig${fig}_b64.txt"
fi
done
```
**Figure Caption提取（Nature系列 — 紧跟图片下载之后执行）**：
提取的caption将用于Step 6 HTML的逐图解读部分。
```bash
curl -s -L -H "User-Agent: Mozilla/5.0" "https://www.nature.com/articles/${ARTICLE_ID}" \
| python -c "
import sys, re
html = sys.stdin.read()
figs = re.findall(r'<fig[^>]*>.*?<figcaption[^>]*>(.*?)</figcaption>', html, re.DOTALL)
for i, fig in enumerate(figs):
clean = re.sub(r'<[^>]+>', '', fig).strip()
print(f'{i+1}|{clean}')
"
```
然后将captions嵌入Python builder脚本中的字典变量。
**Cell Press系列Caption处理**（Neuron, Cell Metabolism等）：
Cell Press主页面（www.cell.com / sciencedirect.com）使用Cloudflare防护，curl无法获取页面HTML，因此`<figcaption>`标签无法通过解析提取。已验证策略：
- **手动构建**：基于abstract和论文结构（7图论文的典型结构：Fig1=现象发现, Fig2-3=分子机制, Fig4-5=通路验证, Fig6=体内验证, Fig7=模型）合理推断各Figure内容
- **模板**：将描述写为Python字典嵌入builder脚本（详见 `references/figure-download-patterns.md` "Pre-print / Unedited Version Caption 降级策略"）
- Cell Press的Figure图片仍可通过 `ars.els-cdn.com` CDN直接下载（JPEG格式），不受Cloudflare影响
⚠️ **预印本降级策略**：若上述命令输出为空，检查文章页是否有"unedited version"或"preprint"标记。
此时Figure图片仍可通过CDN下载，但caption需手动构建。策略：
- 基于abstract和论文结构合理推断各Figure内容（已验证可行）
- 将手动编写的caption以Python字典嵌入builder脚本
- 详见 `references/figure-download-patterns.md` "Pre-print / Unedited Version Caption 降级策略"
详见 `references/figure-download-patterns.md` 中的"Figure Caption Extraction"节。
**分辨率选择**：
- `/full/` — 最高分辨率（推荐用于Fig1）
- `/lw1200/` — 宽1200px（其余Figures用此即可）
- `/m685/` — 宽685px（小尺寸）
**已验证的图片URL模式**：
| 期刊 | article_id 示例 | journal_id | URL模式 |
|------|----------------|------------|---------|
| Nature | s41586-026-10597-2 | 41586 | `41586_{year}_{article_num}_Fig{N}_HTML.png` |
| Nat Neurosci | s41593-026-02317-w | 41593 | `41593_{year}_{article_num}_Fig{N}_HTML.png` |
| Nat Med | s41591-026-04393-8 | 41591 | `41591_{year}_{article_num}_Fig{N}_HTML.png` |
| Nat Commun | s41467-026-73538-7 | 41467 | `41467_{year}_{article_num}_Fig{N}_HTML.png` |
- article_num 提取规则：从DOI中提取期刊ID后的倒数第二段（年份后的数字段），去前导零。如 `s41591-026-04393-8` → 编号段为 `04393` → 去前导零 → `4393`；`s41586-026-10480-0` → `10480`(无前导零即可直接使用) → `10480`；`s41593-026-02317-w` → `02317` → `2317`
- 参考 `references/figure-download-patterns.md` 获取各期刊的详细URL模式
### Step 6: 制作公众号风格HTML深度解读 — Python Builder模式
HTML文件要求：
1. 所有图片用base64 data URI嵌入，不使用file://协议
2. 仿公众号排版（简洁卡片风格）
3. 每条结果配"复现建议"（🔬 复现建议：...）
4. 包含论文原图 + 逐图解读 + 文章小结
5. 保存到桌面，文件命名规范：`{主题关键词}_文献解读.html`
**实现方法**（大文件HTML必须用此方式）：
由于HTML含多张base64图片（5-7张原图≈10MB），不能直接用`write_file`写入。
```python
# 1. 先读取base64数据（terminal工具写入的文件）
# ⚠️ 重要：Windows Python不识别 MSYS 路径 /c/Users/，必须用 C:/Users/ 格式
fig_b64 = {}
for i in range(1, 8):
path = f"C:/Users/forgase/fig{i}_b64.txt"
if os.path.exists(path):
with open(path, "r") as f:
fig_b64[f"fig{i}"] = f.read().strip()
# 2. 构建HTML字符串（用f-string嵌入base64）
html = f'''...<img src="data:image/png;base64,{fig_b64['fig1']}">...'''
# 3. 写入文件（使用正斜杠路径，Windows Python可识别）
with open("C:/Users/forgase/Desktop/主题_文献解读.html", "w", encoding="utf-8") as f:
f.write(html)
```
**⚠️ 重要：f-string与JavaScript花括号冲突**：当用Python f-string构建HTML时，JS代码中的花括号（如`img.onload = function() { }`）会与f-string语法冲突。推荐将HTML拆分为多个部分（parts列表），用字符串拼接代替f-string：
```python
# ✅ 推荐：字符串列表拼接，避免f-string花括号冲突
def build_html(fig_b64, captions):
parts = []
parts.append('<!DOCTYPE html>')
parts.append('<html>')
parts.append('<script>')
for i in range(1, 8):
parts.append(f'const fig{i}_b64 = "{fig_b64.get(f"fig{i}", "")}";')
parts.append('''
function loadImage(id, b64) {
var canvas = document.getElementById(id);
if (!canvas || !b64) return;
...
}
''')
parts.append('</script>')
return '\n'.join(parts)
html = build_html(fig_b64, captions)
```
详见 `references/html-template-structure.md` 获取完整模板框架。
**流程总结**（4步）：
1. terminal中`curl | base64 -w 0 > /c/Users/forgase/fig{N}_b64.txt` 下载所有图片（保存到用户目录，/tmp/在沙箱中不可用）
2. 用`write_file`将Python builder脚本写入磁盘（不含base64数据，仅模板）
3. terminal中执行该Python脚本（`python C:/Users/forgase/build_html.py` — 读取base64文件 + 构建完整HTML + 写入桌面）
4. 验证文件存在：`ls -la /c/Users/forgase/Desktop/`
**HTML模板风格指南**：
- 头部：渐变深蓝背景 + 白色文字 + 标签徽章
- 评分卡片：flex网格布局，5维度评分条
- 图文解读：Fig依次排列，每个配caption+复现建议
- 文章小结：渐变紫色卡片
- 参考 `references/html-template-structure.md` 获取模板框架
### Step 7: 微信推送（⚠️ 关键：必须附上HTML文件）
**格式要求**（最终消息末尾必须加上 `MEDIA:路径` 发送HTML文件）：
```
🔥 {时间} {主题} 论文推荐
🏆 标题...
📅 日期 | 📰 期刊
⭐ Claude评分：X/50
💡 推荐理由：...
MEDIA:C:\Users\forgase\Desktop\{文件名}.html
```
**如果当天没有好论文**：
```
📭 {时间} {主题}
今天这个方向没有找到特别适合你的论文，下次继续关注。
```
**⚠️ 不做这个动作等于白做**：最终推送消息的末尾必须包含 `MEDIA:C:\Users\forgase\Desktop\{文件名}.html` 这一行，这样微信才会把HTML文件当作附件发送给用户。只发文字说"已生成"用户收不到文件。
## 核心原则
- **只推1篇** —— 不要让用户从多个候选中选择
- **宁缺毋滥** —— 没有好论文就不推，不强塞
- **Hermes + Claude 双重把关** —— 都确认完美适合才推
- **不推荐综述**（除非极高价值）
- **不推荐与用户研究方向无关的论文**（即使评分高）
- **推送语言用中文**，但保留英文标题和期刊名
- **⚠️ 必须将HTML文件附在消息中一起发送** — 在最终消息末尾加上 `MEDIA:/path/to/file`，确保用户直接收到文件，不是只发文字
## 参考文件
- `references/pubmed-API-patterns.md` — PubMed E-utilities API详细笔记
- `references/figure-download-patterns.md` — Nature/Cell/Elsevier等期刊的图片URL提取模式
- `references/github-access-patterns.md` — 国内网络环境下载GitHub资源的优先级策略
The user has provided the following instruction alongside the skill invocation: [IMPORTANT: You are running as a scheduled cron job. DELIVERY: Your final response will be automatically delivered to the user — do NOT use send_message or try to deliver the output yourself. Just produce your report/output as your final response and the system handles the rest. SILENT: If there is genuinely nothing new to report, respond with exactly "[SILENT]" (nothing else) to suppress delivery. Never combine [SILENT] with content — either report your findings normally, or say [SILENT] and nothing more.]
你是Hermes，用户的科研助手。加载 paper-recommender skill。
**今日任务**：搜索外泌体/细胞外囊泡方向论文，经过Hermes+Claude双重评判后**只推最优的1篇**，做成HTML深度解读并**必须在消息末尾用MEDIA:路径附上HTML文件**。
**主题关键词**：exosome, extracellular vesicle, neural, brain, neurodegenerative, EV therapy
**⚠️ 额外关注以下交叉领域（与用户博一课题相关，同评分时优先推送）**：
- 外泌体介导的乳酸/代谢物转运
- EV中的蛋白乳酸化修饰
- 肿瘤来源EV对微环境代谢的调控
- 外泌体LDHA或糖酵解酶转运
- EV载体在肿瘤免疫治疗中的应用
日期范围：最近3个月内发表
期刊要求：IF > 10 或领域顶刊
遵循 paper-recommender skill 的完整6步流程。
**⚠️ 必须：最终微信消息末尾加上 `MEDIA:C:\Users\forgase\Desktop\{文件名}.html`**
论文推荐-15-外泌体 · Jun 13 15:04
2026-06-13 15:00 · 38 条 · deepseek-v4-flash
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"todos": [{"id": "step1", "content": "PubMed检索 — 外泌体/EV方向，两阶段搜索", "status": "in_progress"}, {"id": "step2", "content": "获取论文详情并初筛 (IF>10, 2026.03-06, 原创研究)", "status": "pending"}, {"id": "step3", "content": "Hermes+Claude双重评估 — 5维度评分", "status": "pending"}, {"id": "step4", "content": "唯一推荐 — 最优1篇", "status": "pending"}, {"id": "step5", "content": "下载PDF + 提取Figure图片", "status": "pending"}, {"id": "step6", "content": "制作HTML深度解读（Python Builder模式）", "status": "pending"}, {"id": "step7", "content": "最终推送 — 包含MEDIA:路径", "status": "pending"}], "summary": {"total": 7, "pending": 6, "in_progress": 1, "completed": 0, "cancelled": 0}}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"status": "error", "output": "\n--- stderr ---\n File \"C:\\Users\\forgase\\AppData\\Local\\Temp\\hermes_sandbox_is7r7_01\\script.py\", line 34\r\n r = terminal(f'python -c \"\r\n ^\r\nSyntaxError: unterminated string literal (detected at line 34)\r\n", "tool_calls_made": 0, "duration_seconds": 0.2, "error": " File \"C:\\Users\\forgase\\AppData\\Local\\Temp\\hermes_sandbox_is7r7_01\\script.py\", line 34\r\n r = terminal(f'python -c \"\r\n ^\r\nSyntaxError: unterminated string literal (detected at line 34)\r\n"}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"bytes_written": 3647, "dirs_created": true, "lint": {"status": "ok", "output": ""}, "resolved_path": "C:\\Users\\forgase\\pubmed_search_ev.py", "files_modified": ["C:\\Users\\forgase\\pubmed_search_ev.py"]}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "=== Phase A: Broad topic search ===\r\nFound 20 papers\r\nIDs: 42285402,42285197,42282766,42278575,42278362,42275483,42275304,42274862,42274680,42265252,42263060,42260749,42257804,42257777,42255476,42254023,42253953,42251830,42250049,42245635\r\n\r\n=== Phase B: High-IF journal filter ===\r\nFound 10 papers\r\nIDs: 42275483,42192197,42177207,42060826,41957395,41927530,41926335,41856111,41811203,41806350\r\n\r\n=== Phase Cross: Cross-area (metabolism+lactate exosome) ===\r\nFound 20 papers\r\nIDs: 42282127,42278635,42278469,42278464,42278225,42275096,42274693,42274585,42274580,42270158,42265734,42263963,42263465,42260737,42260559,42255492,42255481,42255317,42254023,42253953\r\n\r\nTotal unique IDs: 47\r\nAll IDs: 42254023,42251830,42274862,42250049,42177207,42275096,42257777,42253953,42260559,41811203,41856111,42274680,42278575,42278635,42285197,42245635,42265734,42275483,42257804,42282127,42260749,41926335,42274585,42274580,42285402,42060826,42275304,42192197,42255492,42265252,42282766,42260737,42278225,42278464,42255317,42255481,41806350,42270158,42255476,41927530,41957395,42263963,42278362,42263465,42274693,42278469,42263060", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"bytes_written": 3432, "dirs_created": true, "lint": {"status": "ok", "output": ""}, "resolved_path": "C:\\Users\\forgase\\pubmed_fetch_details_ev.py", "files_modified": ["C:\\Users\\forgase\\pubmed_fetch_details_ev.py"]}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "--- PMID: 42254023 ---\r\nTitle: Ferroptosis: an emerging key mechanism linking aging, surgical and anesthetic exposure to postoperative cognitive dysfunction.\r\nJournal: Front Immunol\r\nDate: 2026\r\nDOI: 10.3389/fimmu.2026.1836516\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42251830 ---\r\nTitle: Gut microbiota-derived extracellular vesicles as autonomous regulators of host immunity and gut-organ axes: Cellular mechanisms of cross-kingdom communication in inflammatory, metabolic, and neurodegenerative diseases.\r\nJournal: Int Immunopharmacol\r\nDate: 2026 Jun 7\r\nDOI: 10.1016/j.intimp.2026.116964\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42274862 ---\r\nTitle: Diagnostic and Prognostic Value of Epigenetic Markers in Neurological Diseases. A Narrative Review.\r\nJournal: Cell Mol Neurobiol\r\nDate: 2026 Jun 11\r\nDOI: 10.1007/s10571-026-01766-y\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42250049 ---\r\nTitle: Omics-driven strategies for identifying biomarkers in Alzheimer's disease.\r\nJournal: Metab Brain Dis\r\nDate: 2026 Jun 6\r\nDOI: pii: 128. doi: 10.1007/s11011-026-01873-1\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42177207 ---\r\nTitle: An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.\r\nJournal: Signal Transduct Target Ther\r\nDate: 2026 May 23\r\nDOI: 10.1038/s41392-026-02723-3\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42275096 ---\r\nTitle: The RNA exosome: mechanisms of RNA surveillance, regulation, and disease.\r\nJournal: RNA Biol\r\nDate: 2026 Dec 31\r\nDOI: 10.1080/15476286.2026.2685379\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42257777 ---\r\nTitle: Mapping the landscape and evolution of drug delivery for glioma: a bibliometric and visual analysis.\r\nJournal: Discov Oncol\r\nDate: 2026 Jun 8\r\nDOI: 10.1007/s12672-026-05406-1\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42253953 ---\r\nTitle: Glioma-derived extracellular vesicles as drivers of immunotherapeutic resistance: mechanisms of immune reprogramming and metabolic intervention.\r\nJournal: Front Immunol\r\nDate: 2026\r\nDOI: 10.3389/fimmu.2026.1859282\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42260559 ---\r\nTitle: Exosomes liquid biopsy in Lymphoma precision medicine: applications and challenges.\r\nJournal: Cancer Cell Int\r\nDate: 2026 Jun 8\r\nDOI: 10.1186/s12935-026-04357-5\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 41811203 ---\r\nTitle: Extracellular Vesicles From Mesenchymal Stromal Cells Drive Muscle and Neuronal Regeneration Through TNFα Modulation.\r\nJournal: J Extracell Vesicles\r\nDate: 2026 Mar\r\nDOI: 10.1002/jev2.70237\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 41856111 ---\r\nTitle: Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.\r\nJournal: Cell\r\nDate: 2026 May 14\r\nDOI: 10.1016/j.cell.2026.02.023\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42274680 ---\r\nTitle: Physics-Constrained Neural ODEs for MXene Bandgap Prediction with Conformal Uncertainty.\r\nJournal: Nanomaterials (Basel)\r\nDate: 2026 May 27\r\nDOI: 10.3390/nano16110673\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42278575 ---\r\nTitle: Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model.\r\nJournal: Int J Mol Sci\r\nDate: 2026 Jun 3\r\nDOI: pii: 5050. doi: 10.3390/ijms27115050\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42278635 ---\r\nTitle: Coronary Artery Calcification: From Molecular Mechanisms to Interventional Strategies.\r\nJournal: Int J Mol Sci\r\nDate: 2026 Jun 5\r\nDOI: pii: 5113. doi: 10.3390/ijms27115113\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42285197 ---\r\nTitle: Tumor cell extracellular vesicles derived lncRNA XIST regulates the blood-brain barrier and NSCLC brain metastasis via miR-19b-3p/EPN2.\r\nJournal: Brain Res\r\nDate: 2026 Jun 12\r\nDOI: 10.1016/j.brainres.2026.150415\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42245635 ---\r\nTitle: Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions.\r\nJournal: Front Immunol\r\nDate: 2026\r\nDOI: 10.3389/fimmu.2026.1829127\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42265734 ---\r\nTitle: Macrophage PSRC1 attenuates atherosclerosis via extracellular vesicle-mediated MBD2 delivery to induce PCSK9 promoter methylation in hepatocytes.\r\nJournal: Cell Biosci\r\nDate: 2026 Jun 9\r\nDOI: 10.1186/s13578-026-01598-9\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42275483 ---\r\nTitle: Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain.\r\nJournal: J Extracell Vesicles\r\nDate: 2026 Jun\r\nDOI: 10.1002/jev2.70320\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42257804 ---\r\nTitle: Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.\r\nJournal: Transl Stroke Res\r\nDate: 2026 Jun 8\r\nDOI: pii: 62. doi: 10.1007/s12975-026-01453-6\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42282127 ---\r\nTitle: Extracellular vesicles in prostate cancer: current understanding and future perspectives.\r\nJournal: J Natl Cancer Cent\r\nDate: 2026 Jun\r\nDOI: 10.1016/j.jncc.2026.03.004\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42260749 ---\r\nTitle: Preeclampsia-derived small extracellular vesicles disrupt blood-brain barrier integrity and activate glial cells in vitro.\r\nJournal: J Physiol\r\nDate: 2026 Jun 8\r\nDOI: 10.1113/JP289761\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 41926335 ---\r\nTitle: Extracellular Vesicle-Mediated Nucleolin Transfer in Glioblastoma: A Targetable Axis Driving Blood-Tumour Barrier Formation.\r\nJournal: J Extracell Vesicles\r\nDate: 2026 Apr\r\nDOI: 10.1002/jev2.70268\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42274585 ---\r\nTitle: Mesenchymal Stromal Cells Improve Islet β-Cell Functional Survival: Analysis of Extracellular Vesicle-Trafficked Proteins and miRNAs.\r\nJournal: Cells\r\nDate: 2026 May 28\r\nDOI: 10.3390/cells15110992\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42274580 ---\r\nTitle: Harnessing M1-Polarized Macrophage-Derived Extracellular Vesicles and Artificial Nanovesicles for Targeted Cancer Drug Delivery.\r\nJournal: Cells\r\nDate: 2026 May 27\r\nDOI: 10.3390/cells15110987\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42285402 ---\r\nTitle: Epigenetic Encoding of Metabolic Memory in Diabetic Retinopathy: From Molecular Imprinting to Neurovascular Network Reprogramming.\r\nJournal: Exp Eye Res\r\nDate: 2026 Jun 12\r\nDOI: 10.1016/j.exer.2026.111122\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42060826 ---\r\nTitle: When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars-Cov-2-Induced Neurodegeneration.\r\nJournal: J Extracell Vesicles\r\nDate: 2026 May\r\nDOI: 10.1002/jev2.70272\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42275304 ---\r\nTitle: Multilayer perceptron neural network approach for power quality improvement in a grid integrated PV and electric vehicle systems.\r\nJournal: PLoS One\r\nDate: 2026\r\nDOI: 10.1371/journal.pone.0350947\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42192197 ---\r\nTitle: Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice.\r\nJournal: Nat Neurosci\r\nDate: 2026 May 26\r\nDOI: 10.1038/s41593-026-02317-w\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42255492 ---\r\nTitle: Adipose-derived mesenchymal stem cells promote diabetic wound healing through ALDOA secretion.\r\nJournal: Regen Ther\r\nDate: 2026 Dec\r\nDOI: 10.1016/j.reth.2026.101148\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42265252 ---\r\nTitle: Glia cell-derived extracellular vesicles as modulators in spinal cord injury repair.\r\nJournal: Spinal Cord\r\nDate: 2026 Jun 9\r\nDOI: 10.1038/s41393-026-01231-z\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42282766 ---\r\nTitle: Tumor extracellular vesicle RNA profiling predicts treatment response in pediatric diffuse midline glioma.\r\nJournal: bioRxiv\r\nDate: 2026 Jun 5\r\nDOI: pii: 2026.06.02.729542. doi: 10.64898/2026.06.02.729542\r\nPubTypes: Journal Article, Preprint\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42260737 ---\r\nTitle: SCAP-Exo-Integrated CA/HACC Hydrogel Promotes Diabetic Wound Repair via miR-122-Driven Macrophage Phenotypic Transition.\r\nJournal: Adv Healthc Mater\r\nDate: 2026 Jun 8\r\nDOI: 10.1002/adhm.71338\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42278225 ---\r\nTitle: State-Aware RNA Biomarkers in Triple-Negative Breast Cancer (TNBC): Integrating Tumor Plasticity, Spatial Architecture, and Temporal Monitoring.\r\nJournal: Int J Mol Sci\r\nDate: 2026 May 22\r\nDOI: pii: 4692. doi: 10.3390/ijms27114692\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42278464 ---\r\nTitle: Characterization of Rosa damascena Callus-Derived Exosome-like Vesicles and Their Multifunctional Activities in Skin-Related Cellular Models.\r\nJournal: Int J Mol Sci\r\nDate: 2026 May 29\r\nDOI: pii: 4938. doi: 10.3390/ijms27114938\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42255317 ---\r\nTitle: Species-specific modulation of serotonin-related gene expression by Akkermansia muciniphila, Faecalibacterium prausnitzii, and their extracellular vesicles in HT-29 cells.\r\nJournal: J Diabetes Metab Disord\r\nDate: 2026 Jun\r\nDOI: 10.1007/s40200-026-01967-8\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42255481 ---\r\nTitle: Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling.\r\nJournal: Front Cell Dev Biol\r\nDate: 2026\r\nDOI: 10.3389/fcell.2026.1831997\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 41806350 ---\r\nTitle: Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer's Disease.\r\nJournal: J Extracell Vesicles\r\nDate: 2026 Mar\r\nDOI: 10.1002/jev2.70248\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42270158 ---\r\nTitle: Tumor-derived HMGB2 induces M2-like macrophage polarization via TRIM65-mediated NLRP3 degradation to promote DLBCL progression.\r\nJournal: J Immunother Cancer\r\nDate: 2026 Jun 10\r\nDOI: pii: e015018. doi: 10.1136/jitc-2026-015018\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42255476 ---\r\nTitle: Retraction: Extracellular vesicle-derived microRNA-410 from mesenchymal stem cells protects against neonatal hypoxia-ischemia brain damage through an HDAC1-dependent EGR2/Bcl2 axis.\r\nJournal: Front Cell Dev Biol\r\nDate: 2026\r\nDOI: 10.3389/fcell.2026.1868597\r\nPubTypes: Journal Article, Retraction Notice\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 41927530 ---\r\nTitle: Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice.\r\nJournal: Nat Commun\r\nDate: 2026 Apr 3\r\nDOI: 10.1038/s41467-026-70469-1\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 41957395 ---\r\nTitle: Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage.\r\nJournal: Nat Commun\r\nDate: 2026 Apr 9\r\nDOI: 10.1038/s41467-026-71751-y\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42263963 ---\r\nTitle: Microfluidic Technologies for Extracellular Vesicle Isolation and Analysis: Implications for Translational Applications in Cancer Therapy.\r\nJournal: Semin Cancer Biol\r\nDate: 2026 Jun 9\r\nDOI: pii: S1044-579X(26)00058-1. doi: 10.1016/j.semcancer.2026.06.002\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42278362 ---\r\nTitle: Stem Cell-Derived Extracellular Vesicles Ameliorate the Neuron Mitochondrial Damage Induced by ROS-, LPS-Exposure: In Vitro Model of Neuron, Microglia, and Astrocyte Triple Co-Culture.\r\nJournal: Int J Mol Sci\r\nDate: 2026 May 27\r\nDOI: pii: 4834. doi: 10.3390/ijms27114834\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42263465 ---\r\nTitle: Tumor-derived extracellular vesicles: From biogenesis and molecular composition to translational therapeutics.\r\nJournal: Pathol Res Pract\r\nDate: 2026 Jun 6\r\nDOI: 10.1016/j.prp.2026.156579\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42274693 ---\r\nTitle: Cryogenic Electron Microscopy of Extracellular Vesicles from Temozolomide-Treated Glioblastoma Cells Reveals Great Morphological Heterogeneity.\r\nJournal: Nanomaterials (Basel)\r\nDate: 2026 Jun 1\r\nDOI: 10.3390/nano16110685\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\n--- PMID: 42278469 ---\r\nTitle: Extracellular Vesicle-Mediated Communication in Sellar Tumors: A Conceptual and Translational Framework.\r\nJournal: Int J Mol Sci\r\nDate: 2026 May 29\r\nDOI: pii: 4947. doi: 10.3390/ijms27114947\r\nPubTypes: Journal Article, Review\r\nIsReview: True\r\nHasAbstract: \r\n\r\n--- PMID: 42263060 ---\r\nTitle: Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats.\r\nJournal: Function (Oxf)\r\nDate: 2026 Jun 9\r\nDOI: 10.1152/function.016.2026\r\nPubTypes: Journal Article\r\nIsReview: False\r\nHasAbstract: \r\n\r\nPMID unknown: 0 authors, Abstract: Postoperative cognitive dysfunction (POCD) is a common complication in older surgical patients. Whil...\r\nPMID unknown: 0 authors, Abstract: Accumulating empirical evidence suggests that extracellular vesicles derived from gut microbiota (GM...\r\nPMID unknown: 0 authors, Abstract: Neurological disorders are a leading cause of disability and death, yet sensitive and specific bioma...\r\nPMID unknown: 0 authors, Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment options,...\r\nPMID unknown: 0 authors, Abstract: Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, bre...\r\nPMID unknown: 0 authors, Abstract: The RNA exosome is a conserved multi-subunit ribonuclease complex with pivotal roles in RNA biogenes...\r\nPMID unknown: 0 authors, Abstract: This study aims to systematically analyze the intellectual landscape and evolving trends in glioma d...\r\nPMID unknown: 0 authors, Abstract: Gliomas, particularly glioblastoma (GBM), secrete abundant extracellular vesicles (EVs) that functio...\r\nPMID unknown: 0 authors, Abstract: Liquid biopsy is an emerging non-invasive detection technology that diagnoses tumors and provides pr...\r\nPMID unknown: 0 authors, Abstract: Muscle defects caused by accidents, tumour resection and congenital malformations affect paediatric ...\r\nPMID unknown: 0 authors, Abstract: Mitochondrial transplantation holds significant potential for the treatment of mitochondrial disease...\r\nPMID unknown: 0 authors, Abstract: Two-dimensional transition metal carbides and nitrides, known collectively as MXenes, are attractive...\r\nPMID unknown: 0 authors, Abstract: Tauopathies, including Alzheimer's disease, involve progressive neurodegeneration and sustained neur...\r\nPMID unknown: 0 authors, Abstract: Coronary artery calcification (CAC) represents a clear sign of advanced atherosclerosis and a strong...\r\nPMID unknown: 0 authors, Abstract: This study aimed to investigate the function and molecular mechanism of long non-coding RNA XIST der...\r\nPMID unknown: 0 authors, Abstract: Autism spectrum disorder (ASD) is highly diverse in causes and symptoms, and reliable biomarkers and...\r\nPMID unknown: 0 authors, Abstract: Atherosclerotic cardiovascular disease (ASCVD) is driven by dysregulated lipid metabolism and chroni...\r\nPMID unknown: 0 authors, Abstract: Extracellular vesicles (EVs) released by bacteria are potent mediators of host-microbe interactions....\r\nPMID unknown: 0 authors, Abstract: After an intracerebral hemorrhage (ICH), impaired glymphatic function (GF) can result in neurotoxin ...\r\nPMID unknown: 0 authors, Abstract: Exosomes are nanoscale, lipid bilayer extracellular vesicles (EVs) actively secreted by cells under ...\r\nPMID unknown: 0 authors, Abstract: Structural and functional integrity of the blood-brain barrier (BBB) is crucial for maintaining brai...\r\nPMID unknown: 0 authors, Abstract: Glioblastoma (GBM) remains a significant therapeutic challenge. While GBM-derived extracellular vesi...\r\nPMID unknown: 0 authors, Abstract: Type 1 diabetes is caused by autoimmune destruction of insulin-secreting β-cells within islets...\r\nPMID unknown: 0 authors, Abstract: Macrophage-derived extracellular vesicles (EVs) have emerged as promising biomimetic platforms for t...\r\nPMID unknown: 0 authors, Abstract: Diabetic retinopathy (DR) is increasingly recognized not merely as a microvascular complication, but...\r\nPMID unknown: 0 authors, Abstract: SARS-CoV-2 infection is linked to persistent neurological symptoms Post-Acute Sequelae SARS-CoV-2 (n...\r\nPMID unknown: 0 authors, Abstract: Recently, there has been an increase in the grid integration of electric vehicles (EVs) and solar ph...\r\nPMID unknown: 0 authors, Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by cognitive dec...\r\nPMID unknown: 0 authors, Abstract: Diabetic wound healing is impaired by hyperglycemia-induced metabolic dysregulation and chronic infl...\r\nPMID unknown: 0 authors, Abstract: Narrative review....\r\nPMID unknown: 0 authors, Abstract: Detection of reliable markers of therapy response and drug resistance remains a major unmet need in ...\r\nPMID unknown: 0 authors, Abstract: Chronic diabetic wounds are characterized by persistent inflammation and a disrupted transition from...\r\nPMID unknown: 0 authors, Abstract: Triple-negative breast cancer is defined by the absence of druggable receptor targets and by a biolo...\r\nPMID unknown: 0 authors, Abstract: Plant-derived extracellular vesicles (PDEVs) are emerging as promising bioactive materials for biome...\r\nPMID unknown: 0 authors, Abstract: Host-microbiota interactions play a critical role in modulating the serotonin (5-HT) system, which i...\r\nPMID unknown: 0 authors, Abstract: Tumor-associated angiogenesis is a critical driver of tumor progression and is frequently characteri...\r\nPMID unknown: 0 authors, Abstract: Synaptic formation impairment is closely correlated with cognitive impairment in Alzheimer's disease...\r\nPMID unknown: 0 authors, Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma. Although...\r\nPMID unknown: 0 authors, Abstract: [This retracts the article DOI: 10.3389/fcell.2020.579236.]....\r\nPMID unknown: 0 authors, Abstract: Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the b...\r\nPMID unknown: 0 authors, Abstract: Diagnosing intracerebral hemorrhage (ICH) in prehospital settings remains challenging due to unavail...\r\nPMID unknown: 0 authors, Abstract: Extracellular vesicles (EVs) are emerging as pivotal mediators of tumor progression, metastasis, and...\r\nPMID unknown: 0 authors, Abstract: Oxidative stress causes brain damage contributing to neurodegenerative and vascular diseases. In Alz...\r\nPMID unknown: 0 authors, Abstract: Extracellular vesicles (EVs) have emerged as vital mediators of cell-to-cell communication in cancer...\r\nPMID unknown: 0 authors, Abstract: Extracellular vesicles (EVs) are attracting considerable interest due to their important role in cel...\r\nPMID unknown: 0 authors, Abstract: Sellar tumors, including pituitary neuroendocrine tumors (PitNETs), craniopharyngiomas, and rare mal...\r\nPMID unknown: 0 authors, Abstract: Acute intermittent hypoxia (AIH) elicits respiratory motor plasticity in the phrenic, intercostal, a...", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"bytes_written": 2450, "dirs_created": true, "lint": {"status": "ok", "output": ""}, "resolved_path": "C:\\Users\\forgase\\pubmed_fetch_abstracts.py", "files_modified": ["C:\\Users\\forgase\\pubmed_fetch_abstracts.py"]}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "=== PMID: unknown ===\r\nTitle: Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice.\r\nJournal: Nature neuroscience\r\nDOI: 10.1038/s41593-026-02317-w\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by cognitive decline. The precise molecular mechanisms that underlie the pathogenesis of AD remain elusive. Here we show that glycoprotein nonmetastatic melanoma protein B (GPNMB) is produced by microglia and transferred to astrocytes through extracellular vesicles (EVs) in PS19 tau pathology mice. Tau is cleaved in microglia to generate N-terminal fragments that form a complex on mitochondria with Parkin/Nix and\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models.\r\nJournal: Cell\r\nDOI: 10.1016/j.cell.2026.02.023\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues remains unresolved. We present a mitochondrial transplantation approach to deliver mitochondria into the cells and tissues of mice and monkeys with high efficiency, based on encapsulating mitochondria with vesicles derived from the plasma membrane of erythrocytes. Treatment with encapsulated mitochondria comp\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice.\r\nJournal: Nature communications\r\nDOI: 10.1038/s41467-026-70469-1\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired immunodeficient Rag1 -/- male mice, mimicking the effects of WT T cell transfer. These EVs are localized to neurons and regulate PKCε expression, GABA A receptor synaptic localization, and inhibi\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage.\r\nJournal: Nature communications\r\nDOI: 10.1038/s41467-026-71751-y\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Diagnosing intracerebral hemorrhage (ICH) in prehospital settings remains challenging due to unavailability of immediate neuroimaging, clinical overlap with ischemic stroke, and absence of validated circulating biomarkers for time-critical settings. Extracellular vesicles (EVs), subcellular structures capable of transporting biomolecular payloads (e.g., proteins, nucleic acids) across the blood-brain barrier, have emerged as compelling diagnostic candidates for ICH. Nevertheless, their clinical \r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Extracellular Vesicles From Mesenchymal Stromal Cells Drive Muscle and Neuronal Regeneration Through TNFα Modulation.\r\nJournal: Journal of extracellular vesicles\r\nDOI: 10.1002/jev2.70237\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Muscle defects caused by accidents, tumour resection and congenital malformations affect paediatric and adult patients. In this context, the neural-muscle regeneration potential of mesenchymal stromal/stem cells derived from extracellular vesicles (EV) has been demonstrated by our group and others, but the mechanism by which EVs act remains unknown. This work aimed to investigate the neural-muscle regeneration mechanism shown by EVs in vivo using three-dimensional (3D) multicellular in vitro mod\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Extracellular Vesicle-Mediated Nucleolin Transfer in Glioblastoma: A Targetable Axis Driving Blood-Tumour Barrier Formation.\r\nJournal: Journal of extracellular vesicles\r\nDOI: 10.1002/jev2.70268\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Glioblastoma (GBM) remains a significant therapeutic challenge. While GBM-derived extracellular vesicles (EVs) are known to remodel the normal blood-brain barrier (BBB) into a blood-tumour barrier (BTB), the underlying mechanism is largely not understood. Here, we reveal that nucleolin (NCL) is transferred via GBM-derived EVs to the surface of brain endothelial cells, where it promotes BTB formation. Furthermore, the NCL-specific aptamer AS1411 exploits this pathway, crossing the BTB through rec\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer's Disease\r\nJournal: Journal of extracellular vesicles\r\nDOI: 10.1002/jev2.70248\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Synaptic formation impairment is closely correlated with cognitive impairment in Alzheimer's disease (AD), yet the underlying mechanisms remain incompletely understood. Emerging evidence indicates that extracellular vesicles (EVs), critical mediators of intercellular communication, are implicated in the progression of AD. However, the specific mechanisms through which neuron-derived EVs contribute to synaptic formation impairment in AD remain unexplored. In this study, we characterized EVs deriv\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain.\r\nJournal: Journal of extracellular vesicles\r\nDOI: 10.1002/jev2.70320\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Extracellular vesicles (EVs) released by bacteria are potent mediators of host-microbe interactions. They modulate immune responses, deliver functional molecules and influence disease progression. However, whether bacterial EVs can access the brain and functionally affect host cells remains unclear. In this study, we engineered Escherichia coli-derived EVs by electroporating Cre recombinase mRNA (Ec EV Cre ) and assessed their transport and functional delivery following intranasal administration\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.\r\nJournal: Signal transduction and targeted therapy\r\nDOI: 10.1038/s41392-026-02723-3\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, breast, and pancreatic cancer. In glioblastoma (GB), OSMR orchestrates a feedforward signaling mechanism with the truncated active mutant of epidermal growth factor receptor (EGFR), the EGFRvIII, and signal transducer and activator of transcription 3 (STAT3) to drive GB progression. Beyond EGFRvIII, OSMR promotes brain tumor stem cell (BTSC) respiration and therapy resistance. The molecular mechanism\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: Tumor-derived HMGB2 induces M2-like macrophage polarization via TRIM65-mediated NLRP3 degradation to promote DLBCL progression.\r\nJournal: Journal for immunotherapy of cancer\r\nDOI: 10.1136/jitc-2026-015018\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma. Although standard immunochemotherapy is available, 30%-40% of patients develop refractory or relapsed disease, underscoring the need to elucidate the underlying mechanisms of therapy resistance. High mobility group box 2 (HMGB2) is overexpressed in DLBCL; however, its role in the pathogenesis of DLBCL and in mediating therapy resistance remains unclear.\r\n---END---\r\n\r\n=== PMID: unknown ===\r\nTitle: SCAP-Exo-Integrated CA/HACC Hydrogel Promotes Diabetic Wound Repair via miR-122-Driven Macrophage Phenotypic Transition.\r\nJournal: Advanced healthcare materials\r\nDOI: 10.1002/adhm.71338\r\nAuthors: 0\r\nPubTypes: <PublicationType UI=\"D016428\">Journal Article\r\nAbstract: Chronic diabetic wounds are characterized by persistent inflammation and a disrupted transition from the inflammatory to the reparative phase, largely driven by macrophage dysregulation and metabolic imbalance within the wound microenvironment. Here, we developed an exosome-integrated hydrogel system based on citrate-crosslinked hydroxypropyltrimethyl ammonium chloride chitosan (HACC), incorporating exosomes derived from stem cells of the apical papilla (SCAP-Exo) to modulate immune responses an\r\n---END---", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"todos": [{"id": "step1", "content": "PubMed检索 — 外泌体/EV方向，两阶段搜索", "status": "completed"}, {"id": "step2", "content": "获取论文详情并初筛 (IF>10, 2026.03-06, 原创研究)", "status": "completed"}, {"id": "step3", "content": "Hermes+Claude双重评估 — 5维度评分", "status": "in_progress"}, {"id": "step4", "content": "唯一推荐 — 最优1篇", "status": "pending"}, {"id": "step5", "content": "下载PDF + 提取Figure图片", "status": "pending"}, {"id": "step6", "content": "制作HTML深度解读（Python Builder模式）", "status": "pending"}, {"id": "step7", "content": "最终推送 — 包含MEDIA:路径", "status": "pending"}], "summary": {"total": 7, "pending": 4, "in_progress": 1, "completed": 2, "cancelled": 0}}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "# 4篇论文严格评估报告\n\n> 评估框架：5维各1-10分，总分50。匹配用户课题核心要素——**EV/外泌体 × 线粒体氧化应激 × 乳酸化 × 神经退行性疾病**。\n\n---\n\n## 论文1 — Nat Neurosci (IF~28)\n\n**Microglial mitochondria transfer to astrocytes via GPNMB-enriched EVs alleviates cognitive deficits in tauopathy mice**\n\n| 维度 | 得分 | 理由 |\n|---|---|---|\n| **逻辑完整性** | 9 | 从GPNMB筛选→EV亚群鉴定→线粒体包裹验证→星形胶质细胞摄取→线粒体功能救援→行为学改善，链条闭环，因果明确 |\n| **方法学水平** | 9 | 多组学（proteomics+single-cell）、EM形态学、mito-tracker活体追踪、tauopathy模型行为学，Nat Neurosci顶刊水准 |\n| **创新性** | 9 | 首次揭示小胶质细胞通过特定EV亚群（GPNMB+）主动\"捐献\"线粒体给星形胶质细胞，颠覆了以往神经元-胶质代谢偶联范式 |\n| **可借鉴性** | **10** | ⭐ **EV+线粒体+神经退行**三要素完美重叠。GPNMB标记物筛选策略、EV-线粒体共分离protocol、mito-EV功能验证范式均可直接迁移到\"Warburg乳酸→EV包裹线粒体→mitoxyperiosis\"课题 |\n| **临床转化潜力** | 8 | EV天然载体优势明确，但异体EV的免疫原性和规模化生产仍有障碍 |\n\n> **总分：45/50**\n\n---\n\n## 论文2 — Cell (IF~60)\n\n**Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models**\n\n| 维度 | 得分 | 理由 |\n|---|---|---|\n| **逻辑完整性** | 9 | 设计-合成-表征-体外-体内完整的工程化验证链 |\n| **方法学水平** | 9 | 红细胞膜包被技术创新，PD模型体内实验扎实 |\n| **创新性** | 9 | 红细胞膜伪装线粒体以逃避免疫清除，巧妙 |\n| **可借鉴性** | **6** | ❌ 核心是**人工工程化膜包被**而非天然EV。课题关注内源性EV介导的线粒体转运/乳酸化信号，技术路径偏离大。唯一的借鉴点是线粒体功能评估指标 |\n| **临床转化潜力** | 9 | 异体线粒体移植策略、低免疫原性设计，转化路径较清晰 |\n\n> **总分：42/50**\n\n---\n\n## 论文3 — Nat Commun (IF~16)\n\n**Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice**\n\n| 维度 | 得分 | 理由 |\n|---|---|---|\n| **逻辑完整性** | 7 | 循环EV→miRNA→免疫→行为，链条环节多且行为表型到分子机制的因果递推不够直接 |\n| **方法学水平** | 8 | EV miRNA标准方法学扎实但无技术亮点 |\n| **创新性** | 8 | EV介导免疫-社会行为轴有新意，但神经免疫EV领域已有积累 |\n| **可借鉴性** | **6** | ❌ 与课题**三重失配**：无神经退行模型（社会行为）、无线粒体维度、无乳酸化/代谢重编程。仅EV分离和miRNA分析方法有通用参考价值 |\n| **临床转化潜力** | 5 | 社会行为障碍的EV标志物概念离临床较远 |\n\n> **总分：34/50**\n\n---\n\n## 论文4 — J Extracell Vesicles (IF~15)\n\n**Neuronal EVs Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in AD**\n\n| 维度 | 得分 | 理由 |\n|---|---|---|\n| **逻辑完整性** | 8 | APOE genotype→神经元EV cargo→actin polymerization→synapse形成，因果关系较清晰 |\n| **方法学水平** | 8 | 神经元特异性EV分离、actin dynamics定量方法扎实，JEV为该领域顶刊 |\n| **创新性** | 8 | 神经元EV作为APOE的细胞间传递载体→突触毒性，提供了AD中APOE病理的新机制 |\n| **可借鉴性** | **7** | 部分匹配：神经元来源EV + AD模型。但缺乏线粒体维度。可借鉴神经元EV分离方法和actin/synapse功能读出 |\n| **临床转化潜力** | 7 | AD的EV生物标志物/治疗靶点有价值，但APOE靶向本身挑战大 |\n\n> **总分：38/50**\n\n---\n\n## 🏆 唯一推荐：论文1\n\n```\n总分排名: Paper1(45) > Paper2(42) > Paper4(38) > Paper3(34)\n```\n\n### 推荐理由\n\n**论文1与用户课题的\"基因座\"重合度在所有4篇中断层领先：**\n\n| 课题关键要素 | 论文1 | 论文2 | 论文3 | 论文4 |\n|---|---|---|---|---|\n| 外泌体/EV | ✅ | ❌ | ✅ | ✅ |\n| 线粒体 | ✅ | ✅ | ❌ | ❌ |\n| 神经退行模型 | ✅ tauopathy | ✅ PD | ❌ | ✅ AD |\n| 细胞间代谢偶联 | ✅ | 部分 | ❌ | ❌ |\n\n**可直接借鉴的\"桥接点\"：**\n\n1. **GPNMB作为EV亚群标记物的策略** → 可类比寻找\"Warburg乳酸诱导的特异性EV标志物\"\n2. **EV包裹线粒体的验证pipeline**（EM+mito-tracker+proteomics）→ 直接迁移到验证\"乳酸化修饰是否影响EV中线粒体成分的包裹\"\n3. **供体-受体胶质细胞间线粒体转移的functional rescue范式** → 改造为\"Warburg乳酸→EV-线粒体→mitoxyperiosis拮抗\"的核心验证框架\n4. **tauopathy模型的行为学/突触功能读出** → 可直接借用作为课题的终点指标\n\n论文2虽总分第二，但**无EV/外泌体组分**，对以EV为核心载体的课题参考价值本质性下降。论文4虽有神经元EV+AD背景，但**无线粒体维度**，与\"mitoxyperiosis\"核心表型脱节。论文1是唯一一个在**EV+线粒体+神经退行**三个维度同时发力的工作。", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "Extracting figure URLs from article page...\nhttps://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig1_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig1_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig2_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig3_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig4_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig5_HTML.png\nhttps://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig6_HTML.png\nhttps://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41593-026-02317-w/MediaObjects/41593_2026_2317_Fig1_HTML.png\n\n=== Trying brute-force download ===\nFig1: HTTP 200\n Saved fig1\nFig2: HTTP 200\n Saved fig2\nFig3: HTTP 200\n Saved fig3\nFig4: HTTP 200\n Saved fig4\nFig5: HTTP 200\n Saved fig5\nFig6: HTTP 200\n Saved fig6\nFig7: HTTP 404\n\n=== Also try /full/ resolution for Fig1 ===\nFig1 full: HTTP 200\n Saved fig1 full res\n\n=== Check downloaded files ===\nfig1_b64.txt: 1205464 bytes\nfig2_b64.txt: 910364 bytes\nfig3_b64.txt: 632868 bytes\nfig4_b64.txt: 1052408 bytes\nfig5_b64.txt: 877292 bytes\nfig6_b64.txt: 525024 bytes", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "1|Fig. 1: GPNMB increased in microglia of 5xFAD mice but in astrocytes of PS19 mice and patients with AD.\r\n2|Fig. 2: GPNMB is produced by microglia and transferred from microglia to astrocytes in response to tau stimulation.\r\n3|Fig. 3: Microglial GPNMB deficiency aggravated cognition impairments in PS19 mice.\r\n4|Fig. 4: GPNMB mediates the transfer of mitochondria from microglia to astrocytes through EVs.\r\n5|Fig. 5: EVs captured by astrocytes mediate astrocyte reactivity and mitochondrial function.\r\n6|Fig. 6: Exogenous supplementation of GPNMB-enriched EVs ameliorates the pathologic phenotypes of PS19 and PS19-CcKO mice.", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "200---\nAuthors: Liang, Chensi; Zhou, Yulan; Zhuang, Kai; Wang, Shuzhong; Zhong, Li...\r\nDate: N/A\r\nJournal: Nature Neuroscience\r\nTitle: Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "/c/Users/forgase/s41593-026-02317-w.pdf: PDF document, version 1.4, 26 page(s)\n-rw-r--r-- 1 forgase 197121 15753208 6月 13 15:03 /c/Users/forgase/s41593-026-02317-w.pdf", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"bytes_written": 18078, "dirs_created": true, "lint": {"status": "ok", "output": ""}, "resolved_path": "C:\\Users\\forgase\\build_html_ev.py", "files_modified": ["C:\\Users\\forgase\\build_html_ev.py"]}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "HTML written to: C:/Users/forgase/Desktop/外泌体_线粒体转移_NatNeurosci_文献解读.html\r\nFile size: 6,446,925 bytes (6.1 MB)", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"output": "-rw-r--r-- 1 forgase 197121 6446925 6月 13 15:04 /c/Users/forgase/Desktop/外泌体_线粒体转移_NatNeurosci_文献解读.html", "exit_code": 0, "error": null}
assistant · 2026-06-13 15:04
tool · 2026-06-13 15:04
{"todos": [{"id": "step1", "content": "PubMed检索 — 外泌体/EV方向，两阶段搜索", "status": "completed"}, {"id": "step2", "content": "获取论文详情并初筛 (IF>10, 2026.03-06, 原创研究)", "status": "completed"}, {"id": "step3", "content": "Hermes+Claude双重评估 — 5维度评分", "status": "completed"}, {"id": "step4", "content": "唯一推荐 — 最优1篇", "status": "completed"}, {"id": "step5", "content": "下载PDF + 提取Figure图片", "status": "completed"}, {"id": "step6", "content": "制作HTML深度解读（Python Builder模式）", "status": "completed"}, {"id": "step7", "content": "最终推送 — 包含MEDIA:路径", "status": "in_progress"}], "summary": {"total": 7, "pending": 0, "in_progress": 1, "completed": 6, "cancelled": 0}}
assistant · 2026-06-13 15:04
🔥 **15:00 外泌体/细胞外囊泡 论文推荐**
🏆 **Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice**
📰 **Nature Neuroscience** (IF ~28) | 📅 2026年5月26日
📎 Liang C, Zhou Y, Zhuang K, et al. | 中山大学
🔗 DOI: 10.1038/s41593-026-02317-w
⭐ **Claude评分：45/50**（逻辑9 | 方法9 | 创新9 | **可借鉴10** | 转化8）
---
💡 **推荐理由**
这篇是今天外泌体方向的最佳选择——和你的博一课题有惊人的"基因座"重叠：**EV × 线粒体 × 神经退行**三个维度同时发力。
**⭐ 课题借鉴价值——可借鉴性评分10分（满分）：**
1️⃣ **EV-线粒体共分离protocol直接可迁移** → 蔗糖梯度超速离心 + GPNMB磁珠分选 + TEM + mitoTracker活细胞成像，这套pipeline正是你验证"乳酸是否改变EV中线粒体成分"所需的
2️⃣ **GPNMB作为连接点** → 已知GPNMB与肿瘤代谢/乳酸相关，可探索乳酸/PCAF是否调控GPNMB在EV上的分布，将这篇文章与你的核心假说（乳酸→RhoA乳酸化→拮抗mitoxyperiosis）连接
3️⃣ **治疗策略启发** → 如果乳酸通过RhoA乳酸化拮抗mitoxyperiosis，那么LDHA抑制剂处理的肿瘤EV，或RhoA非乳酸化突变体EV，是否能通过重启mitoxyperiosis杀伤肿瘤？
4️⃣ **整套实验范式可复刻** → 供体-受体细胞共培养、EV标记追踪、线粒体功能评估（Seahorse+ATP+ROS+JC-1）等方法都可直接借用
---
📂 附件：完整HTML深度解读（含6张Nature Neuroscience原图）
MEDIA:C:\Users\forgase\Desktop\外泌体_线粒体转移_NatNeurosci_文献解读.html