论文推荐-13-细胞死亡 · Jun 11 13:11

{"success": true, "name": "paper-recommender", "description": "每日定时推送高质量论文推荐 — PubMed检索 → Hermes+Claude双重评估 → 仅推最优1篇 → HTML深度解读", "tags": ["PubMed", "论文推荐", "Claude评估", "文献解读", "科研"], "related_skills": [], "content": "---\nname: paper-recommender\ndescription: \"每日定时推送高质量论文推荐 — PubMed检索 → Hermes+Claude双重评估 → 仅推最优1篇 → HTML深度解读\"\nversion: 2.1.0\nauthor: Hermes\ntags: [PubMed, 论文推荐, Claude评估, 文献解读, 科研]\n---\n\n# 📚 每日论文推荐工作流 (Paper Recommender)\n\n## 职责\n根据用户的6个研究兴趣方向，每日定时从PubMed检索近期高质量论文，经过Hermes+Claude双重评估后，**只选最优的1篇**，下载PDF+提取原图，制作公众号风格的HTML深度解读文件并推送。\n\n## 用户研究方向\n1. 帕金森病(PD) / GZR18 / α-synuclein\n2. 神经炎症 / 小胶质细胞 / 星形胶质细胞\n3. 细胞死亡方式 (Mitoxyperiosis / 铁死亡 / 焦亡 / 泛素化降解)\n4. 外泌体 / 细胞外囊泡 / 神经退行性疾病\n5. 脑缺血 / 脑卒中 / 神经保护\n6. 生信分析 / 单细胞测序 / 多组学\n\n## 定时推送安排\n\n| 时间 | 主题 | 关键词 |\n|:----:|------|--------|\n| 08:00 | PD/帕金森病 | Parkinson's disease, α-synuclein, MPTP, dopamine neuron |\n| 11:00 | 神经炎症/胶质细胞 | neuroinflammation, microglia, astrocyte, NLRP3 |\n| 13:00 | 细胞死亡/信号通路 | cell death, mitoxyperiosis, ferroptosis, ubiquitination |\n| 15:00 | 外泌体/细胞通讯 | exosome, extracellular vesicle, neural, brain |\n| 17:00 | 脑缺血/神经保护 | cerebral ischemia, stroke, neuroprotection, MCAO |\n| 19:00 | 生信/前沿技术 | single-cell, multi-omics, bioinformatics, spatial transcriptomics |\n\n## 执行流程（完整版）\n\n### Step 1: PubMed检索 — 两阶段策略\n\n**方式：Python urllib**（推荐，避免curl的SSL/编码问题）\n```python\nimport urllib.request, urllib.parse, json\nparams = {\n 'db': 'pubmed', 'term': query,\n 'mindate': '<3个月前>', 'maxdate': '<今天>',\n 'datetype': 'pdat', 'retmax': 15, 'retmode': 'json'\n}\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?' + urllib.parse.urlencode(params)\n```\n\n**阶段A — 主题搜索**：用关键词搜该方向近期论文\n**阶段B — 高IF期刊过滤**：用主题词 + `(\"Nature\"[Journal] OR \"Cell\"[Journal] OR ...)` 格式搜\n\n⚠️ 关键陷阱：\n- `sort=date` 被PubMed忽略（返回warning），不要用\n- 期刊名必须用 `\"全称\"[Journal]` 格式，裸词会被翻译为MeSH词条\n- 复杂查询在curl中容易URL编码失败，优先用Python\n\n### Step 2: 获取论文详情并初筛\n\n```python\n# 获取元数据\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&id=<PMIDs>&retmode=json'\n# 获取摘要\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=<PMIDs>&retmode=xml'\n```\n\n**初筛硬性门槛**（必须同时满足）：\n1. IF > 10 或领域顶刊\n2. 2026年3月后发表\n3. 与用户研究方向直接相关\n4. 原创研究（pubtype不含Review）\n5. 非 News & Views / Letter / 编辑评论\n\n### Step 3: Claude Code深度评估（Hermes + Claude 双重评判）\n\n将经过初筛的候选论文交给 Claude Code 严格评估：\n```\nclaude -p \"严格评估以下论文，从5个维度各评1-10分...\"\n```\n\n**5维度评分**：\n1. **逻辑完整性** (1-10)：完整正反验证（gain+loss of function）、KO/KI模型\n2. **方法学水平** (1-10)：前沿技术（单细胞测序、冷冻电镜、活细胞成像、TurboID等）\n3. **创新性** (1-10)：新概念/新机制/新方法，首次报道\n4. **可借鉴性** (1-10)：实验设计是否值得用户在自己的课题中参考 **← 这是最关键的维度**\n5. **临床转化潜力** (1-10)：体内验证或治疗意义\n\n### Step 4: 唯一推荐（核心规则）\n\n- Claude评分 < 30分（平均<6分）或任何单维度 < 5分 → **不推荐**，跳过\n- 多个候选都达标 → **只选最优的1篇**，不要让用户选\n- Hermes再次确认质量 + 相关性 + 可借鉴性 → 只有双方都确认才通过\n- **如果这篇研究方向不匹配（如planarian flatworm研究），即使评分高也不能推**\n\n### Step 5: 下载PDF + 提取Figure图片\n\n**PDF下载**：\n- Nature: `https://www.nature.com/articles/{article_id}.pdf`\n- Cell: (可能需要其他方式)\n- 注意：部分期刊有付费墙，PDF可能无法下载，此时跳过\n\n**Figure提取**（Nature模式已验证）：\n- 从文章HTML页面提取图片URL：`https://www.nature.com/articles/{article_id}`\n- 图片URL格式：`https://media.springernature.com/full/springer-static/image/art%3A10.1038%2F{article_id}/MediaObjects/{journal_id}_{year}_{article_num}_Fig{N}_HTML.png`\n- 替换路径中的 `lw1200/` 为 `full/` 获取高分辨率版本\n- 参考 `references/figure-download-patterns.md` 获取各期刊的详细URL模式\n\n### Step 6: 制作公众号风格HTML深度解读\n\nHTML文件要求：\n1. 所有图片用JS变量(base64)嵌入，不使用file://协议\n2. 仿公众号排版（简洁卡片风格）\n3. 每条结果配\"复现建议\"（🔬 复现建议：...）\n4. 包含论文原图 + 逐图解读 + 文章小结\n5. 保存到桌面，文件命名规范：`{主题关键词}_文献解读.html`\n\n### Step 7: 微信推送\n\n**格式要求**：\n```\n🔥 {时间} {主题} 论文推荐\n\n🏆 标题...\n📅 日期 | 📰 期刊\n⭐ Claude评分：X/50\n💡 推荐理由：...\n\n（解读HTML已生成，请查收）\n```\n\n**如果当天没有好论文**：\n```\n📭 {时间} {主题}\n今天这个方向没有找到特别适合你的论文，下次继续关注。\n```\n\n## 核心原则\n- **只推1篇** —— 不要让用户从多个候选中选择\n- **宁缺毋滥** —— 没有好论文就不推，不强塞\n- **Hermes + Claude 双重把关** —— 都确认完美适合才推\n- **不推荐综述**（除非极高价值）\n- **不推荐与用户研究方向无关的论文**（即使评分高）\n- **推送语言用中文**，但保留英文标题和期刊名\n\n## 参考文件\n- `references/pubmed-API-patterns.md` — PubMed E-utilities API详细笔记\n- `references/figure-download-patterns.md` — Nature/Cell/Elsevier等期刊的图片URL提取模式\n", "path": "productivity\\paper-recommender\\SKILL.md", "skill_dir": "C:\\Users\\forgase\\AppData\\Local\\hermes\\skills\\productivity\\paper-recommender", "linked_files": {"references": ["references\\figure-download-patterns.md", "references\\pubmed-API-patterns.md"]}, "usage_hint": "To view linked files, call skill_view(name, file_path) where file_path is e.g. 'references/api.md' or 'assets/config.yaml'", "required_environment_variables": [], "required_commands": [], "missing_required_environment_variables": [], "missing_credential_files": [], "missing_required_commands": [], "setup_needed": false, "setup_skipped": false, "readiness_status": "available"}

{"success": true, "name": "paper-recommender", "file": "references/pubmed-API-patterns.md", "content": "# PubMed E-utilities API 实战笔记\n\n## 搜索API (esearch)\n\n### 基础结构\n```\nbase: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi\nparams:\n db=pubmed\n term=<查询表达式>\n mindate/maxdate — 日期范围\n datetype=pdat (publication date)\n retmax=N — 最大返回数\n retmode=json\n```\n\n### 已验证的关键查询模式\n\n**1. 主题搜索 + 高影响因子期刊过滤**\n```python\nquery = 'Parkinson AND (\"Nat Neurosci\"[Journal] OR \"Neuron\"[Journal] OR \"Nat Med\"[Journal])'\n```\n- 期刊名必须用 `\"全称\"[Journal]` 格式\n- 不加 `[Journal]` 标签时，`Neuron` 被翻译为 MeSH 的 neurons（神经元）\n- `Brain` 被翻译为 MeSH 的 brain（大脑解剖结构）\n\n**2. 细胞死亡方向搜索（已验证）**\n```python\nquery = '(ferroptosis[Title/Abstract] OR pyroptosis[Title/Abstract] OR ' + \\\n 'necroptosis[Title/Abstract] OR PANoptosis[Title/Abstract] OR ' + \\\n 'cuproptosis[Title/Abstract] OR mitophagy[Title/Abstract]) ' + \\\n 'AND (Nature[Journal] OR \"Cell\"[Journal] OR \"Nat Cell Biol\"[Journal] OR ' + \\\n '\"Cell Death Differ\"[Journal] OR \"Nat Commun\"[Journal])'\n```\n这个模式成功返回了 Nature 的精胺/铁死亡论文。\n\n**3. 已测试的有效期刊标签**\n| 期刊 | 标签 |\n|------|------|\n| Nature | `\"Nature\"[Journal]` |\n| Nature Communications | `\"Nat Commun\"[Journal]` |\n| Nature Medicine | `\"Nat Med\"[Journal]` |\n| Neuron | `\"Neuron\"[Journal]` |\n| Nature Neuroscience | `\"Nat Neurosci\"[Journal]` |\n| Science Advances | `\"Sci Adv\"[Journal]` |\n| Cell | `\"Cell\"[Journal]` |\n| Cell Reports | `\"Cell Rep\"[Journal]` |\n| Cell Death & Differentiation | `\"Cell Death Differ\"[Journal]` |\n| EMBO Journal | `\"EMBO J\"[Journal]` |\n| Molecular Neurodegeneration | `\"Mol Neurodegener\"[Journal]` |\n| EBioMedicine | `\"EBioMedicine\"[Journal]` |\n| Acta Neuropathologica | `\"Acta Neuropathol\"[Journal]` |\n| Brain | `\"Brain\"[Journal]` |\n| Lancet Neurology | `\"Lancet Neurol\"[Journal]` |\n| Developmental Cell | `\"Dev Cell\"[Journal]` |\n| Nature Structural & Molecular Biology | `\"Nat Struct Mol Biol\"[Journal]` |\n| Cell Metabolism | `\"Cell Metab\"[Journal]` |\n| Molecular Cell | `\"Mol Cell\"[Journal]` |\n\n### 已验证无用的参数\n- `sort=date` — 返回 warning \"Unknown sort schema 'date' ignored\"，无效果\n\n## 获取详情API (esummary)\n\n```python\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&id=<PMID列表>&retmode=json'\n```\n\n关键字段：\n- `pubtype` — 文章类型（含 \"Review\" 则为综述）\n- `source` — 期刊缩写名\n- `articleids[].idtype == 'doi'` — DOI\n- `attributes` — 包含 \"Has Abstract\" 则有摘要\n- `pubdate` — 发表日期\n- `title` — 标题\n\n## 获取摘要API (efetch)\n\n```python\n# XML模式（含结构化信息）\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=<PMIDs>&retmode=xml'\n\n# 文本模式（纯文本）\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=<PMIDs>&retmode=text&rettype=abstract'\n```\n\nXML模式返回结构化数据，适合用正则提取：\n- `<ArticleTitle>` → 标题\n- `<AbstractText>` → 摘要段落（可以有多段）\n- `<ELocationID EIdType=\"doi\">` → DOI\n- `<Journal><Title>` → 期刊全名（最后一个匹配是英文名）\n- `<PubDate><Year>` + `<Month>` → 发表日期\n\n## 获取文章元数据（XML完整模式）\n\n```python\nurl = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=<PMIDs>&retmode=xml'\n```\n此模式返回完整XML，包含：\n- 所有作者的 `<LastName>` 和 `<ForeName>`\n- 所有 `<Keyword>`\n- 完整 `<AbstractText>`\n- `<PublicationTypeList>` 用于排除Review/Letter\n\n## 已知环境陷阱\n\n### 1. SSL连接失败（exit code 35）\n某些环境（git-bash/MSYS2）的 curl SSL 版本与 NCBI 服务器不兼容。\n- 修复1：`curl -k`（跳过证书验证）\n- 修复2：改用 Python 的 `urllib.request`（在本环境中工作可靠）\n- 修复3：更新 curl CA bundle\n\n### 2. URL编码问题\ncurl 命令行中包含 `()\"[]` 等特殊字符时容易解析失败（exit code 3）。\n- 修复：用 Python 的 `urllib.parse.urlencode(params)` 构建查询串\n\n### 3. `sort=date` 无效\nPubMed API 不支持 sort=date，搜索结果的顺序按默认相关性排序。\n\n### 4. Cell/Elsevier 付费墙\nCell Press（www.cell.com、linkinghub.elsevier.com）对脚本访问严格限制，返回403/超时。Nature系列（www.nature.com）通常可正常访问。\n\n## 搜索策略（两阶段工作流）\n\n### 阶段A：主题搜索\n```python\nquery = 'Parkinson disease AND (dopamine neuron OR synuclein OR MPTP)'\nparams = {\n 'db': 'pubmed', 'term': query,\n 'mindate': '<3月前>', 'maxdate': '<今天>',\n 'datetype': 'pdat', 'retmax': 10, 'retmode': 'json'\n}\n```\n目的：了解该时段总论文数，获取基础PMID列表。\n\n### 阶段B：高影响力期刊过滤\n```python\njournal_tags = '\"Nature\"[Journal] OR \"Cell\"[Journal] OR \"Nat Neurosci\"[Journal] OR ...'\nquery = f'({topic_keywords}) AND ({journal_tags})'\n```\n目的：直接命中IF>10的高质量论文。\n\n### 初筛要点\n1. `pubtype` 不含 \"Review\" → 原创研究\n2. `attributes` 含 \"Has Abstract\" → 有摘要\n3. 检查 DOI 是否存在\n4. 排除 \"No authors listed\" → 通常是 News & Views\n\n## 评分标准（Claude评估用，5维度各1-10分）\n\n| 维度 | 评分要点 | 满分 |\n|------|---------|------|\n| 逻辑完整性 | gain+loss of function, KO/KI, 正反验证 | 10 |\n| 方法学水平 | 单细胞测序, 冷冻电镜, 活细胞成像, TurboID等 | 10 |\n| 创新性 | 新概念/新机制/新方法 | 10 |\n| 可借鉴性 | 实验设计可迁移到神经科学 **←最重要维度** | 10 |\n| 临床转化潜力 | 体内验证, 治疗靶点, 生物标志物 | 10 |\n\n总分 >= 30 且各维度 >= 5 → 候选。再经Hermes确认相关性后，只选最优1篇。\n", "file_type": ".md"}

{"success": true, "name": "paper-recommender", "file": "references/figure-download-patterns.md", "content": "# 学术期刊Figure下载模式速查\n\n## Nature 系列\n**已验证模式（2026年6月）**\n\n### URL结构\n```\n文章页: https://www.nature.com/articles/{article_id}\nFigure URL: https://media.springernature.com/full/springer-static/image/\n art%3A10.1038%2F{article_id}/MediaObjects/\n {journal_id}_{year}_{article_num}_Fig{N}_HTML.png\n```\n\n### 关键参数\n- `{article_id}`: DOI中`/`后面的部分，如 `s41586-026-10597-2`\n- `{journal_id}`: 期刊对应数字ID，如 Nature=41586\n- `{year}`: 4位年份\n- `{article_num}`: 文章编号\n- `{N}`: Figure编号（1-7）\n\n### 分辨率控制\n| 前缀 | 尺寸 | 说明 |\n|------|------|------|\n| `/full/` | 全尺寸 | 最高分辨率，推荐使用 |\n| `/lw1200/` | 宽1200px | 中等尺寸 |\n| `/m685/` | 宽685px | 小尺寸 |\n| `/w215h120/` | 215x120px | 缩略图 |\n\n### 提取策略（Python/requests）\n```python\nimport re, requests\n\nhtml = requests.get(f\"https://www.nature.com/articles/{article_id}\").text\n# 找到所有Figure URL\npattern = r'(https://media\\.springernature\\.com/[^\"\\'<>]+'\npattern += f'{article_id.replace(\"-\", \"_\")}[^\"\\'<>]*\\\\.(?:jpg|png|webp))'\nmatches = re.findall(pattern, html)\n```\n\n### 已测试的期刊ID\n| 期刊 | ID |\n|------|----|\n| Nature | 41586 |\n| Nature Communications | 41467 |\n| Cell Death & Differentiation | 41418 |\n| Scientific Reports | 41598 |\n| Cell Discovery | 41420 |\n\n## Cell Press / Elsevier 系列\n**注意：Cell Press有强付费墙，以下模式仅供参考**\n\n### 典型URL模式\n```\nhttps://www.cell.com/cms/10.1016/j.{journal_abbr}.{year}.{article_id}/asset/\n{hash}/main.assets/gr{N}_large.jpg\n```\n\n### 备选CDN路径\n```\nhttps://els-jbs-prod-cdn.jbs.elsevierhealth.com/journals/{journal_abbr}/\n...\nhttps://www.cell.com/cell/fulltext/{pii}\n```\n- Cell Press 2025年起对脚本访问限制严格（403）\n- 建议通过 PubMed Central OA 获取，或使用付费订阅机构的访问\n\n## PMC / PubMed Central 开放获取\n```\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC{pmcid}/bin/{filename}\n```\n- 仅对开放获取文章有效\n\n## 通用最佳实践\n\n1. **先获取文章HTML页面**，从中提取Figure图片链接\n2. **优先使用全尺寸版本**（替换路径中的尺寸限定词）\n3. **base64嵌入**到HTML中，避免file://协议被浏览器拦截\n4. **文件命名**：`Figure{N}_{简短描述}.png`（从HTML的figure标签中获取描述）\n5. **注意付费墙**：3xx/4xx响应 → 放弃，不要反复重试\n", "file_type": ".md"}

{"todos": [{"id": "1", "content": "PubMed检索 — 两阶段策略搜索细胞死亡相关论文", "status": "in_progress"}, {"id": "2", "content": "获取论文详情 + 摘要 + 初筛", "status": "pending"}, {"id": "3", "content": "Claude Code深度评估候选论文", "status": "pending"}, {"id": "4", "content": "选最优1篇并Hermes确认", "status": "pending"}, {"id": "5", "content": "下载PDF + 提取Figure图片", "status": "pending"}, {"id": "6", "content": "制作公众号风格HTML深度解读", "status": "pending"}, {"id": "7", "content": "输出最终推荐报告", "status": "pending"}], "summary": {"total": 7, "pending": 6, "in_progress": 1, "completed": 0, "cancelled": 0}}

{"status": "success", "output": "URL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28ferroptosis%5BTitle%2FAbstract%5D+OR+pyroptosis%5BTitle%2FAbstract%5D+OR+necroptosis%5BTitle%2FAbstract%5D+PANoptosis%5B...\r\n\r\n=== 阶段B: 高IF期刊检索结果 ===\r\nTotal results: 132\r\nIDs found: ['42259916', '42248910', '42243520', '42236947', '42236938', '42236908', '42234560', '42229422', '42228571', '42228568', '42225830', '42218155', '42213853', '42207639', '42204371', '42203761', '42202783', '42185292', '42176266', '42174122']\r\n❌ Error: [Errno 2] No such file or directory: '/tmp/pubmed_ids.txt'\r\n", "tool_calls_made": 0, "duration_seconds": 0.61}

{"status": "success", "output": "Got 20 paper summaries\r\n\r\nPMID: 42259916\r\n 标题: Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding.\r\n 期刊: Nature\r\n 日期: 2026 Jun 8\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41586-026-10738-7\r\n 作者: Zeng J ... Doudna JA\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42248910\r\n 标题: HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack.\r\n 期刊: Nat Commun\r\n 日期: 2026 Jun 5\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41467-026-74022-y\r\n 作者: Zhang Y ... Yang W\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42243520\r\n 标题: Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival.\r\n 期刊: EMBO J\r\n 日期: 2026 Jun 4\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s44318-026-00815-y\r\n 作者: Sainz de la Maza D ... Amoyel M\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42236947\r\n 标题: Spermine is an endogenous iron chelator that inhibits ferroptosis.\r\n 期刊: Nature\r\n 日期: 2026 Jun 3\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41586-026-10597-2\r\n 作者: Li M ... Li J\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42236938\r\n 标题: Cold-induced peptide signalling secures pollen resilience and crop yield.\r\n 期刊: Nature\r\n 日期: 2026 Jun 3\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41586-026-10603-7\r\n 作者: Chen S ... Xu C\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42236908\r\n 标题: Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.\r\n 期刊: Cell Death Differ\r\n 日期: 2026 Jun 3\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41418-026-01775-w\r\n 作者: Rong Y ... Kroemer G\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42234560\r\n 标题: Synchronous spatiotemporal control of autophagy and organelle trafficking is necessary for infection by Magnaporthe oryz\r\n 期刊: Cell Rep\r\n 日期: 2026 Jun 3\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.celrep.2026.117396\r\n 作者: Eseola AB ... Talbot NJ\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42229422\r\n 标题: Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense.\r\n 期刊: Cell\r\n 日期: 2026 Jun 2\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.cell.2026.05.008\r\n 作者: Chai C ... Wang B\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42228571\r\n 标题: SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma.\r\n 期刊: Cell Rep\r\n 日期: 2026 Jun 1\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.celrep.2026.117481\r\n 作者: Hu Q ... Yu B\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42228568\r\n 标题: Nociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone release.\r\n 期刊: Cell Rep\r\n 日期: 2026 Jun 1\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.celrep.2026.117457\r\n 作者: Meng H ... Wang Y\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42225830\r\n 标题: Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.\r\n 期刊: Nat Cell Biol\r\n 日期: 2026 Jun 1\r\n 类型: ['Journal Article', 'Review']\r\n DOI: 10.1038/s41556-026-01972-2\r\n 作者: Argenziano MG ... Banu MA\r\n 有摘要: True\r\n\r\n ❌ 排除: Review\r\n\r\nPMID: 42218155\r\n 标题: Single-phage profiling illuminates viral individuality during bacterial cell fate determination.\r\n 期刊: Nat Commun\r\n 日期: 2026 May 30\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41467-026-73867-7\r\n 作者: Homaee E ... Golding I\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42213853\r\n 标题: Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.\r\n 期刊: Sci Adv\r\n 日期: 2026 May 29\r\n 类型: ['Journal Article']\r\n DOI: 10.1126/sciadv.aeb2368\r\n 作者: Brenner M ... Gohla A\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42207639\r\n 标题: USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and neck squamous cell \r\n 期刊: Cell Rep\r\n 日期: 2026 May 28\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.celrep.2026.117467\r\n 作者: Sun A ... Lin J\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42204371\r\n 标题: Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release.\r\n 期刊: Cell Death Differ\r\n 日期: 2026 May 27\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41418-026-01769-8\r\n 作者: Gherardi G ... Rizzuto R\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42203761\r\n 标题: Cuproptosis inducers mediate cold lethality via SLCR-46.1 in C. elegans.\r\n 期刊: Nat Commun\r\n 日期: 2026 May 27\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41467-026-73498-y\r\n 作者: Yamashiro S ... Kuhara A\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42202783\r\n 标题: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.\r\n 期刊: Cell Metab\r\n 日期: 2026 May 27\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.cmet.2026.04.020\r\n 作者: Jain C ... Shah YM\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42185292\r\n 标题: Mitochondrial flagella-like extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysregulation in sepsis.\r\n 期刊: Nat Commun\r\n 日期: 2026 May 25\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s41467-026-73523-0\r\n 作者: Hong W ... Duan C\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42176266\r\n 标题: IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death.\r\n 期刊: Cell Rep\r\n 日期: 2026 May 22\r\n 类型: ['Journal Article']\r\n DOI: 10.1016/j.celrep.2026.117441\r\n 作者: Guyot C ... Murray PJ\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\nPMID: 42174122\r\n 标题: Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.\r\n 期刊: EMBO J\r\n 日期: 2026 May 22\r\n 类型: ['Journal Article']\r\n DOI: 10.1038/s44318-026-00809-w\r\n 作者: Jadiya P ... Elrod JW\r\n 有摘要: True\r\n\r\n ✅ 候选论文\r\n\r\n=== 初筛结果: 19篇候选论文 ===\r\n1. Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding.... (Nature, 2026 Jun 8)\r\n2. HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack.... (Nat Commun, 2026 Jun 5)\r\n3. Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival.... (EMBO J, 2026 Jun 4)\r\n4. Spermine is an endogenous iron chelator that inhibits ferroptosis.... (Nature, 2026 Jun 3)\r\n5. Cold-induced peptide signalling secures pollen resilience and crop yield.... (Nature, 2026 Jun 3)\r\n6. Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circula... (Cell Death Differ, 2026 Jun 3)\r\n7. Synchronous spatiotemporal control of autophagy and organelle trafficking is necessary for infection... (Cell Rep, 2026 Jun 3)\r\n8. Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense.... (Cell, 2026 Jun 2)\r\n9. SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma.... (Cell Rep, 2026 Jun 1)\r\n10. Nociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone releas... (Cell Rep, 2026 Jun 1)\r\n11. Single-phage profiling illuminates viral individuality during bacterial cell fate determination.... (Nat Commun, 2026 May 30)\r\n12. Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.... (Sci Adv, 2026 May 29)\r\n13. USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and... (Cell Rep, 2026 May 28)\r\n14. Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine ... (Cell Death Differ, 2026 May 27)\r\n15. Cuproptosis inducers mediate cold lethality via SLCR-46.1 in C. elegans.... (Nat Commun, 2026 May 27)\r\n16. Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.... (Cell Metab, 2026 May 27)\r\n17. Mitochondrial flagella-like extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysreg... (Nat Commun, 2026 May 25)\r\n18. IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death.... (Cell Rep, 2026 May 22)\r\n19. Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.... (EMBO J, 2026 May 22)\r\n\r\nCandidate PMIDs: ['42259916', '42248910', '42243520', '42236947', '42236938', '42236908', '42234560', '42229422', '42228571', '42228568', '42218155', '42213853', '42207639', '42204371', '42203761', '42202783', '42185292', '42176266', '42174122']\r\n", "tool_calls_made": 0, "duration_seconds": 1.01}

{"todos": [{"id": "1", "content": "PubMed检索 — 两阶段策略搜索细胞死亡相关论文", "status": "completed"}, {"id": "2", "content": "获取论文详情 + 摘要 + 初筛", "status": "in_progress"}, {"id": "3", "content": "Claude Code深度评估候选论文", "status": "pending"}, {"id": "4", "content": "选最优1篇并Hermes确认", "status": "pending"}, {"id": "5", "content": "下载PDF + 提取Figure图片", "status": "pending"}, {"id": "6", "content": "制作公众号风格HTML深度解读", "status": "pending"}, {"id": "7", "content": "输出最终推荐报告", "status": "pending"}], "summary": {"total": 7, "pending": 5, "in_progress": 1, "completed": 1, "cancelled": 0}}

{"status": "success", "output": "=== PMID: 42236947 ===\r\n标题: Spermine is an endogenous iron chelator that inhibits ferroptosis.\r\n摘要 (前1000字):\r\nFerroptosis is an iron-dependent form of cell death driven by lipid peroxidation1. Here we identify spermine-a polyamine derived from spermidine2-as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing and biophysical studies of the interaction between spermine and Fe2+ ions, we demonstrate that aldehyde dehydrogenase&#xa0;18 family member A1 (ALDH18A1) promotes an alternative glutamine-dependent pathway for de novo spermine synthesis. This process limits iron availability and lipid peroxidation in hepatocellular carcinoma. Genetic or pharmacological inhibition of ALDH18A1-through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702-triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis. Conversely, supplementation of spermine protects against ferroptosis-associated ischaemia-reperfusion injury across multiple tissues, includin\r\n\r\n---\r\n\r\n=== PMID: 42236908 ===\r\n标题: Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.\r\n摘要 (前1000字):\r\nAcyl-CoA-binding protein (ACBP, encoded by diazepam binding inhibitor, DBI) is an abundant intracellular regulator of lipid metabolism that also circulates systemically, yet the mechanisms governing its release and its relationship to organ injury remain unresolved. Herein, we combine human multi-omics, mechanistic mouse models and controlled cell death assays to identify cell death-driven liberation of intracellular ACBP/DBI as a unifying mechanism underlying its elevation in disease. In a cohort of 1198 hospitalized adults, among whom 75% were acutely infected by SARS-CoV-2, plasma ACBP/DBI tightly correlated with inflammatory markers and biochemical signatures of cardiac, hepatic, renal, metabolic and hematologic dysfunction. SomaScan proteomics further revealed that ACBP/DBI co-varies with organ-enriched proteins, particularly those originating from skeletal muscle and pancreas, implicating tissue injury as a major determinant of its circulating abundance. Multiple forms of acute o\r\n\r\n---\r\n\r\n=== PMID: 42229422 ===\r\n标题: Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense.\r\n摘要 (前1000字):\r\nCurrent understanding of cytotoxic immunity is shaped by hematopoietic-derived cells-T cells, natural killer cells, and neutrophils. Here, we identify \"ruptoblasts,\" a previously unknown cytotoxic glandular cell type in regenerative planarian flatworms. Ruptoblasts undergo an explosive cell death, \"ruptosis,\" triggered by activin, a multifunctional hormone acting as an inflammatory cytokine. Excessive activin-induced through protein injection, genetic chimerism, or bacterial infection-initiates ruptosis, discharging potent diffusible cytotoxic agents capable of eliminating nearby cells, bacteria, and even mammalian cells within minutes. Ruptoblast ablation suppresses inflammation but compromises bacterial clearance, highlighting their broad-spectrum immune functions. Mechanistically distinct from known cytotoxic and cell death mechanisms, the explosive nature of ruptosis relies on endoplasmic reticulum (ER)-derived calcium and cytoskeleton-dependent signal amplification. Ruptoblast-lik\r\n\r\n---\r\n\r\n=== PMID: 42228571 ===\r\n标题: SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma.\r\n摘要 (前1000字):\r\nCuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor-specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcinoma (LUAD), and LUAD cell lines exhibit increased resistance to cuproptosis. Mechanistically, elevated copper stress promotes the expression of the desuccinylase SIRT5 while reducing global succinylation in LUAD cells. Furthermore, we found that SIRT5 is a critical mediator of cuproptosis through the desuccinylation modification on ferredoxin1 (FDX1) protein at Lys84. This modification triggers TRIM8-mediated ubiquitination, leading to FDX1 proteasomal degradation and enhanced cuproptosis resistance. These results reveal the important role of SIRT5 in LUAD cuproptosis resistance. Notably, combining the SIRT5 inhibitor MC3482 with the cuproptosis inducer Elesclomol-Cu synergistically suppresse\r\n\r\n---\r\n\r\n=== PMID: 42213853 ===\r\n标题: Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.\r\n摘要 (前1000字):\r\nModulating ferroptosis, a form of cell death driven by uncontrolled lipid peroxidation, is of interest in numerous diseases. Here, we found that the deletion of phosphoglycolate phosphatase (PGP), an essential enzyme that safeguards high glycolytic flux, suppresses ferroptosis. Using metabolomic and isotopic labeling experiments together with lipid and proteomic profiling, we find that PGP loss drives a rewiring of the pentose phosphate pathway and of cellular energy and lipid metabolism that triggers a multifactorial antioxidant response. Paradoxically, our attempts to block PGP pharmacologically led to the realization that the recently described PGP inhibitor compound 1 (CP1) exerts a strong ferroptosis-sensitizing effect. Using genetic, biochemical, and biophysical approaches, we characterize CP1 as a direct, species-independent, dual inhibitor of PGP and ferroptosis suppressor protein 1 (FSP1), and further find that CP1 triggers FSP1 self-assembly. In sum, we identify PGP as a targ\r\n\r\n---\r\n\r\n=== PMID: 42207639 ===\r\n标题: USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and neck squamous cell \r\n摘要 (前1000字):\r\nFerroptosis is an iron-dependent, lipid-peroxidation-driven cell death mechanism with tumor-suppressive potential, yet its regulatory networks in head and neck squamous cell carcinoma (HNSCC) remain elusive. Here, we identify RAB11FIP5 as a critical negative regulator of ferroptosis in HNSCC cell lines. Mechanistically, RAB11FIP5 competitively sequesters RAB11A to antagonize RAB11FIP1-mediated transferrin and transferrin receptor recycling, thereby restricting iron uptake. We further demonstrate that the deubiquitinase USP52 stabilizes RAB11FIP5 by specifically cleaving K48-linked ubiquitin chains at lysine residues 583 and 586. In addition to ferroptosis, RAB11FIP5 deletion impairs long-term proliferative capacity in vitro. In subcutaneous xenografts, RAB11FIP5 knockout suppresses tumor growth in both the presence and absence of the ferroptosis inducer IKE, operating through both ferroptosis-dependent and -independent mechanisms. Collectively, these findings establish RAB11FIP5 as a d\r\n\r\n---\r\n\r\n=== PMID: 42204371 ===\r\n标题: Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release.\r\n摘要 (前1000字):\r\nMitochondrial Ca2+ uptake shapes cellular signaling by modulating metabolism, cell death and cytosolic Ca2+ dynamics, yet its pathological and therapeutic relevance remains undefined. Here, we show that Ca2+ entry through the mitochondrial Ca2+ uniporter (MCU) is required for mitochondrial fragmentation and subsequent NLRP3 inflammasome-mediated IL-1&#x3b2; release in lipopolysaccharide-primed, stimulated macrophages. This fragmentation occurs independently of the mitochondrial permeability transition pore but depends on activation of the organelle fission machinery. In an inflammatory disease model, MCU deficiency attenuated IL-1&#x3b2; secretion and reduced monosodium urate (MSU) crystal-induced joint inflammation in vivo. Collectively, our findings establish mitochondrial Ca2+ uptake as a key upstream signal that promotes organelle fragmentation to license inflammasome activation, positioning MCU as a potential therapeutic target in inflammatory diseases.\r\n\r\n---\r\n\r\n=== PMID: 42203761 ===\r\n标题: Cuproptosis inducers mediate cold lethality via SLCR-46.1 in C. elegans.\r\n摘要 (前1000字):\r\nCuproptosis denotes cell death triggered by copper accumulation. However, its role in natural environmental responses remains unclear. Here, we demonstrate that cuproptosis contributes to cold-induced lethality in C. elegans. A mutant for the lysosomal copper transporter gene slcr-46.1 exhibited defective cold tolerance due to copper accumulation in the pharyngeal muscle upon cold&#xa0;exposure. The abnormal cold tolerance of the slcr-46.1 mutant was suppressed by interference with copper homeostasis and cuproptosis-signaling genes. Chelating copper ions in the&#xa0;slcr-46.1 mutant rescued the abnormal cold tolerance, while inhibiting cuproptosis signaling in wild-type worms inhibited cold-induced lethality. In addition, the cold lethality in the slcr-46.1 mutant was not caused by activation of the oxidative stress pathway observed in ferroptosis (iron-dependent&#xa0;cell death). Here, we show evidence that cuproptosis plays a critical role in cold-induced lethality in an animal.\r\n\r\n---\r\n\r\n=== PMID: 42202783 ===\r\n标题: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.\r\n摘要 (前1000字):\r\nColorectal cancer (CRC) cells are addicted to iron, which fuels nucleotide synthesis, mitochondrial respiration, and proliferation. Yet paradoxically, high intracellular iron is cytotoxic to most cells, raising the question of how CRC cells tolerate and exploit iron-rich environments. Ferroptosis, an iron-dependent form of cell death, is thought to mediate iron toxicity. However, whether most ferroptosis regulators, identified through synthetic chemical screens or small molecule activators, play a role in modulating iron toxicity, particularly in vivo, remains unclear. Here, using multi-omics profiling, CRISPR screening, and in vivo models, we uncover a heme-succinate dehydrogenase (SDH)-coenzyme Q (CoQ) axis that enables CRC cells to buffer iron-induced oxidative stress. Heme-dependent SDH reduces CoQ, which redistributes to mitochondrial and plasma membranes to detoxify lipid reactive oxygen species (ROS) as a radical-trapping antioxidant. These findings reveal that CRCs co-opt metab\r\n\r\n---\r\n\r\n=== PMID: 42176266 ===\r\n标题: IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death.\r\n摘要 (前1000字):\r\nHigh-risk neuroblastoma (NB) is driven by the amplification of MYCN in conjunction with additional oncogenic mutations in genes encoding kinases such as ALK. NB cells require antioxidant responses to maintain redox balance and are highly sensitive to ferroptosis. Here, we show that metabolites derived from infiltrating immune cells expressing IL4i1, a secreted oxidoreductase, are potent suppressors of NB ferroptosis. IL4i1 metabolites (indole-3-pyruvate and 4-hydroxyphenylpyruvate) blocked ferroptosis in all human NB cell lines via a mechanism that depended on free radical scavenging and NRF2 activation but did not require the aryl hydrocarbon receptor. Supernatant transfer experiments confirmed that IL4i1 creates a milieu that protects NB cells from oxidative cell death. Importantly, mice lacking IL4i1 were protected from NB in a high-penetrance MYCN and mutant ALK-driven autochthonous cancer model. Therefore, we propose that immune IL4i1 is permissive for NB growth and survival. IL4i\r\n\r\n---\r\n\r\n=== PMID: 42174122 ===\r\n标题: Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.\r\n摘要 (前1000字):\r\nLoss of mCa2+ efflux capacity contributes to the pathogenesis and progression of Alzheimer's disease (AD) by promoting mitochondrial Ca2+ (mCa2+) overload. Here, we utilized loss-of-function genetic mouse models to causally evaluate the role of mCa2+ uptake by conditionally deleting the mitochondrial calcium uniporter channel (mtCU) in a robust mouse model of AD. Loss of neuronal mCa2+ uptake reduced A&#x3b2; and tau-pathology, synaptic dysfunction, and cognitive decline in 3xTg-AD mice. Knockdown of Mcu in an in vitro model of AD significantly reduced matrix Ca2+ content, redox imbalance, and mitochondrial dysfunction. The preservation of mitochondrial function rescued the AD-dependent decline in autophagic capacity and protected neurons against amyloidosis and cell death. This was corroborated by in vivo data showing improved mitochondrial structure and apposition in AD mice with loss of neuronal Mcu. These results suggest that inhibition of neuronal mCa2+ uptake represents a powerfu\r\n\r\n---\r\n\r\n=== PMID: 42248910 ===\r\n标题: HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack.\r\n摘要 (前1000字):\r\nCytotoxic lymphocytes use perforin to form plasma membrane (PM) pores in tumor cells, thereby enabling granzyme-mediated cell death. However, whether and how tumor metabolism enables PM repair to evade immunity is unclear. In this study, using a functional screen targeting 111 metabolic enzymes, we identified hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) as critical for repairing perforin-induced PM damage. HMGCS1 promotes PM repair by initiating de novo cholesterol synthesis, enhancing tumor cell resistance to lymphocyte-mediated killing and impairing the efficacy of NK, CAR-T, and anti-PD-1-based immunotherapies. Beyond its structural role, cholesterol directly binds charged multivesicular body protein 4b (CHMP4B) to enhance its PM localization, facilitating PM repair. Furthermore, oncogenic activation, cytokine, and hypoxia induce c-Jun activation, up-regulating HMGCS1 expression. In lung cancer patients, elevated c-Jun activation, HMGCS1 expression, cholesterol content and PM CHMP4\r\n\r\n---\r\n\r\n=== PMID: 42228568 ===\r\n标题: Nociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone release.\r\n摘要 (前1000字):\r\nNeutrophil-involved neuroinflammation in dorsal root ganglion (DRG) plays double-sword roles in chronic pain. How DRG neuron-neutrophil interaction contributes to chronic pain remains unclear. Here, we report that MLKL, a key molecule in necroptosis, is constitutively expressed in the nucleus of nociceptive neurons and binds to histone H3. Periphery inflammation disrupted MLKL/H3 interaction, leading to cytoplasmic translocation of MLKL and release of histone H3. Extracellular histone H3 induces neuronal hyperactivity, neutrophil extracellular trap (NET), and hyperalgesia, possibly through P2X7 receptor and Toll-like receptor 4. Nociceptive-specific depletion of Mlkl significantly decreased pain threshold and exacerbated NET formation independent of cell death. Neutralizing extracellular histone, clearing extracellular DNA or restoring nuclear localization of MLKL can reduce both NET formation and hyperalgesia in Mlkl-/-mice. These data demonstrated that the nociceptive neuron-neutroph\r\n\r\n---\r\n\r\n", "tool_calls_made": 0, "duration_seconds": 1.42}

{"status": "success", "output": "===== PMID: 42236947 =====\r\n📰 期刊: Nature\r\n📝 标题: Spermine is an endogenous iron chelator that inhibits ferroptosis.\r\n👥 作者: Man Li, Xuexin Yu, Shuqin Ouyang ... et al.\r\n\r\n📄 完整摘要:\r\nFerroptosis is an iron-dependent form of cell death driven by lipid peroxidation1. Here we identify spermine-a polyamine derived from spermidine2-as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing and biophysical studies of the interaction between spermine and Fe2+ ions, we demonstrate that aldehyde dehydrogenase&#xa0;18 family member A1 (ALDH18A1) promotes an alternative glutamine-dependent pathway for de novo spermine synthesis. This process limits iron availability and lipid peroxidation in hepatocellular carcinoma. Genetic or pharmacological inhibition of ALDH18A1-through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702-triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis. Conversely, supplementation of spermine protects against ferroptosis-associated ischaemia-reperfusion injury across multiple tissues, including the liver, intestine and kidneys. These findings uncover a pathophysiologically relevant metabolic circuit in which spermine-mediated iron chelation suppresses ferroptosis.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42228571 =====\r\n📰 期刊: Cell reports\r\n📝 标题: SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma.\r\n👥 作者: Qifan Hu, Zuorui Wang, Wenxin Deng ... et al.\r\n🏷️ 关键词: <Keyword MajorTopicYN=\"N\">CP: cancer, CP: molecular biology, FDX1, SIRT5, cuproptosis, lung adenocarcinoma, succinylation\r\n\r\n📄 完整摘要:\r\nCuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor-specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcinoma (LUAD), and LUAD cell lines exhibit increased resistance to cuproptosis. Mechanistically, elevated copper stress promotes the expression of the desuccinylase SIRT5 while reducing global succinylation in LUAD cells. Furthermore, we found that SIRT5 is a critical mediator of cuproptosis through the desuccinylation modification on ferredoxin1 (FDX1) protein at Lys84. This modification triggers TRIM8-mediated ubiquitination, leading to FDX1 proteasomal degradation and enhanced cuproptosis resistance. These results reveal the important role of SIRT5 in LUAD cuproptosis resistance. Notably, combining the SIRT5 inhibitor MC3482 with the cuproptosis inducer Elesclomol-Cu synergistically suppresses tumor growth in vivo, suggesting a promising therapeutic strategy. These findings elucidate mechanisms underlying cuproptosis resistance and propose a novel treatment approach for LUAD.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42213853 =====\r\n📰 期刊: Science advances\r\n📝 标题: Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.\r\n👥 作者: Marian Brenner, Sina H&#xf6;hlein, Paul Wirth ... et al.\r\n\r\n📄 完整摘要:\r\nModulating ferroptosis, a form of cell death driven by uncontrolled lipid peroxidation, is of interest in numerous diseases. Here, we found that the deletion of phosphoglycolate phosphatase (PGP), an essential enzyme that safeguards high glycolytic flux, suppresses ferroptosis. Using metabolomic and isotopic labeling experiments together with lipid and proteomic profiling, we find that PGP loss drives a rewiring of the pentose phosphate pathway and of cellular energy and lipid metabolism that triggers a multifactorial antioxidant response. Paradoxically, our attempts to block PGP pharmacologically led to the realization that the recently described PGP inhibitor compound 1 (CP1) exerts a strong ferroptosis-sensitizing effect. Using genetic, biochemical, and biophysical approaches, we characterize CP1 as a direct, species-independent, dual inhibitor of PGP and ferroptosis suppressor protein 1 (FSP1), and further find that CP1 triggers FSP1 self-assembly. In sum, we identify PGP as a target protein for ferroptosis control and introduce a small-molecule FSP1 inhibitor with unique features to the armamentarium of pharmacological ferroptosis modulators.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42204371 =====\r\n📰 期刊: Cell death and differentiation\r\n📝 标题: Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release.\r\n👥 作者: Gaia Gherardi, Francesca Spinelli, Miriana Sbrissa ... et al.\r\n\r\n📄 完整摘要:\r\nMitochondrial Ca2+ uptake shapes cellular signaling by modulating metabolism, cell death and cytosolic Ca2+ dynamics, yet its pathological and therapeutic relevance remains undefined. Here, we show that Ca2+ entry through the mitochondrial Ca2+ uniporter (MCU) is required for mitochondrial fragmentation and subsequent NLRP3 inflammasome-mediated IL-1&#x3b2; release in lipopolysaccharide-primed, stimulated macrophages. This fragmentation occurs independently of the mitochondrial permeability transition pore but depends on activation of the organelle fission machinery. In an inflammatory disease model, MCU deficiency attenuated IL-1&#x3b2; secretion and reduced monosodium urate (MSU) crystal-induced joint inflammation in vivo. Collectively, our findings establish mitochondrial Ca2+ uptake as a key upstream signal that promotes organelle fragmentation to license inflammasome activation, positioning MCU as a potential therapeutic target in inflammatory diseases.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42174122 =====\r\n📰 期刊: The EMBO journal\r\n📝 标题: Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.\r\n👥 作者: Pooja Jadiya, Elena Berezhnaya, Devin W Kolmetzky ... et al.\r\n\r\n📄 完整摘要:\r\nLoss of mCa2+ efflux capacity contributes to the pathogenesis and progression of Alzheimer's disease (AD) by promoting mitochondrial Ca2+ (mCa2+) overload. Here, we utilized loss-of-function genetic mouse models to causally evaluate the role of mCa2+ uptake by conditionally deleting the mitochondrial calcium uniporter channel (mtCU) in a robust mouse model of AD. Loss of neuronal mCa2+ uptake reduced A&#x3b2; and tau-pathology, synaptic dysfunction, and cognitive decline in 3xTg-AD mice. Knockdown of Mcu in an in vitro model of AD significantly reduced matrix Ca2+ content, redox imbalance, and mitochondrial dysfunction. The preservation of mitochondrial function rescued the AD-dependent decline in autophagic capacity and protected neurons against amyloidosis and cell death. This was corroborated by in vivo data showing improved mitochondrial structure and apposition in AD mice with loss of neuronal Mcu. These results suggest that inhibition of neuronal mCa2+ uptake represents a powerful therapeutic target to impede AD progression.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42207639 =====\r\n📰 期刊: Cell reports\r\n📝 标题: USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and neck squamous cell carcinoma.\r\n👥 作者: Anjiang Sun, Xin Xia, Xiuxian Niu ... et al.\r\n🏷️ 关键词: <Keyword MajorTopicYN=\"N\">CP: cancer, CP: cell biology, Ferroptosis, HNSCC, RAB11A, RAB11FIP5, TFRC, USP52\r\n\r\n📄 完整摘要:\r\nFerroptosis is an iron-dependent, lipid-peroxidation-driven cell death mechanism with tumor-suppressive potential, yet its regulatory networks in head and neck squamous cell carcinoma (HNSCC) remain elusive. Here, we identify RAB11FIP5 as a critical negative regulator of ferroptosis in HNSCC cell lines. Mechanistically, RAB11FIP5 competitively sequesters RAB11A to antagonize RAB11FIP1-mediated transferrin and transferrin receptor recycling, thereby restricting iron uptake. We further demonstrate that the deubiquitinase USP52 stabilizes RAB11FIP5 by specifically cleaving K48-linked ubiquitin chains at lysine residues 583 and 586. In addition to ferroptosis, RAB11FIP5 deletion impairs long-term proliferative capacity in vitro. In subcutaneous xenografts, RAB11FIP5 knockout suppresses tumor growth in both the presence and absence of the ferroptosis inducer IKE, operating through both ferroptosis-dependent and -independent mechanisms. Collectively, these findings establish RAB11FIP5 as a dual regulator of ferroptosis and proliferative capacity, representing a promising therapeutic target in HNSCC.\r\n\r\n================================================================================\r\n\r\n===== PMID: 42202783 =====\r\n📰 期刊: Cell metabolism\r\n📝 标题: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.\r\n👥 作者: Chesta Jain, Muqit Essani, Roshan Kumar ... et al.\r\n🏷️ 关键词: <Keyword MajorTopicYN=\"N\">colorectal cancer, iron toxicity, mitochondrial antioxidant, oxidative stress\r\n\r\n📄 完整摘要:\r\nColorectal cancer (CRC) cells are addicted to iron, which fuels nucleotide synthesis, mitochondrial respiration, and proliferation. Yet paradoxically, high intracellular iron is cytotoxic to most cells, raising the question of how CRC cells tolerate and exploit iron-rich environments. Ferroptosis, an iron-dependent form of cell death, is thought to mediate iron toxicity. However, whether most ferroptosis regulators, identified through synthetic chemical screens or small molecule activators, play a role in modulating iron toxicity, particularly in vivo, remains unclear. Here, using multi-omics profiling, CRISPR screening, and in vivo models, we uncover a heme-succinate dehydrogenase (SDH)-coenzyme Q (CoQ) axis that enables CRC cells to buffer iron-induced oxidative stress. Heme-dependent SDH reduces CoQ, which redistributes to mitochondrial and plasma membranes to detoxify lipid reactive oxygen species (ROS) as a radical-trapping antioxidant. These findings reveal that CRCs co-opt metabolic cofactors both for growth and for survival under physiologically toxic iron levels, uncovering new vulnerabilities for therapy.\r\n\r\n================================================================================\r\n\r\n", "tool_calls_made": 0, "duration_seconds": 1.62}

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[OUTPUT TRUNCATED - 35784 chars omitted out of 85784 total] ...\n\ns iron availability and lipid peroxidation in hepatocellular carcinoma. Genetic or pharmacological inhibition of ALDH18A1&#8212;through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702&#8212;triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis. Conversely, supplementation of spermine protects against ferroptosis-associated ischaemia&#8211;reperfusion injury across multiple tissues, including the liver, intestine and kidneys. These findings uncover a pathophysiologically relevant metabolic circuit in which spermine-mediated iron chelation suppresses ferroptosis. A non-canonical metabolic route for spermine synthesis mediated by ALDH18A1 limits iron availability and lipid peroxidation in hepatocellular carcinoma.\"/>\n <meta name=\"prism.issn\" content=\"1476-4687\"/>\n <meta name=\"prism.publicationName\" content=\"Nature\"/>\n <meta name=\"prism.publicationDate\" content=\"2026-06-03\"/>\n <meta name=\"prism.section\" content=\"OriginalPaper\"/>\n <meta name=\"prism.startingPage\" content=\"1\"/>\n <meta name=\"prism.endingPage\" content=\"11\"/>\n <meta name=\"prism.copyright\" content=\"2026 The Author(s), under exclusive licence to Springer Nature Limited\"/>\n <meta name=\"prism.rightsAgent\" content=\"journalpermissions@springernature.com\"/>\n <meta name=\"prism.url\" content=\"https://www.nature.com/articles/s41586-026-10597-2\"/>\n <meta name=\"prism.doi\" content=\"doi:10.1038/s41586-026-10597-2\"/>\n <meta name=\"citation_pdf_url\" content=\"https://www.nature.com/articles/s41586-026-10597-2.pdf\"/>\n <meta name=\"citation_fulltext_html_url\" content=\"https://www.nature.com/articles/s41586-026-10597-2\"/>\n <meta name=\"citation_journal_title\" content=\"Nature\"/>\n <meta name=\"citation_journal_abbrev\" content=\"Nature\"/>\n <meta name=\"citation_publisher\" content=\"Nature Publishing Group\"/>\n <meta name=\"citation_issn\" content=\"1476-4687\"/>\n <meta name=\"citation_title\" content=\"Spermine is an endogenous iron chelator that inhibits ferroptosis\"/>\n <meta name=\"citation_online_date\" content=\"2026/06/03\"/>\n <meta name=\"citation_firstpage\" content=\"1\"/>\n <meta name=\"citation_lastpage\" content=\"11\"/>\n <meta name=\"citation_article_type\" content=\"Article\"/>\n <meta name=\"citation_language\" content=\"en\"/>\n <meta name=\"dc.identifier\" content=\"doi:10.1038/s41586-026-10597-2\"/>\n <meta name=\"DOI\" content=\"10.1038/s41586-026-10597-2\"/>\n <meta name=\"size\" content=\"341468\"/>\n <meta name=\"citation_doi\" content=\"10.1038/s41586-026-10597-2\"/>\n <meta name=\"citation_springer_api_url\" content=\"http://api.springer.com/xmldata/jats?q=doi:10.1038/s41586-026-10597-2&amp;api_key=\"/>\n <meta name=\"description\" content=\"Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation1. Here we identify spermine&#8212;a polyamine derived from spermidine2&#8212;as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing and biophysical studies of the interaction between spermine and Fe2+ ions, we demonstrate that aldehyde dehydrogenase&amp;nbsp;18 family member A1 (ALDH18A1) promotes an alternative glutamine-dependent pathway for de novo spermine synthesis. This process limits iron availability and lipid peroxidation in hepatocellular carcinoma. Genetic or pharmacological inhibition of ALDH18A1&#8212;through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702&#8212;triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis. Conversely, supplementation of spermine protects against ferroptosis-associated ischaemia&#8211;reperfusion injury across multiple tissues, including the liver, intestine and kidneys. These findings uncover a pathophysiologically relevant metabolic circuit in which spermine-mediated iron chelation suppresses ferroptosis. A non-canonical metabolic route for spermine synthesis mediated by ALDH18A1 limits iron availability and lipid peroxidation in hepatocellular carcinoma.\"/>\n <meta name=\"dc.creator\" content=\"Li, Man\"/>\n <meta name=\"dc.creator\" content=\"Yu, Xuexin\"/>\n <meta name=\"dc.creator\" content=\"Ouyang, Shuqin\"/>\n <meta name=\"dc.creator\" content=\"Chen, Xiaohong\"/>\n <meta name=\"dc.creator\" content=\"Yu, Huiqi\"/>\n <meta name=\"dc.creator\" content=\"Liu, Yuanji\"/>\n <meta name=\"dc.creator\" content=\"Li, Ziwen\"/>\n <meta name=\"dc.creator\" content=\"Yu, Chunhua\"/>\n <meta name=\"dc.creator\" content=\"Kang, Rui\"/>\n <meta name=\"dc.creator\" content=\"Gaillet, Christine\"/>\n <meta name=\"dc.creator\" content=\"Colombeau, Ludovic\"/>\n <meta name=\"dc.creator\" content=\"Rodriguez, Rapha&#235;l\"/>\n <meta name=\"dc.creator\" content=\"Song, Libing\"/>\n <meta name=\"dc.creator\" content=\"Kroemer, Guido\"/>\n <meta name=\"dc.creator\" content=\"Tang, Daolin\"/>\n <meta name=\"dc.creator\" content=\"Li, Jun\"/>\n <meta name=\"dc.subject\" content=\"Cancer therapy\"/>\n <meta name=\"dc.subject\" content=\"Cell death\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cell; citation_title=Ferroptosis: an iron-dependent form of nonapoptotic cell death; citation_author=SJ Dixon; citation_volume=149; citation_publication_date=2012; citation_pages=1060-1072; citation_doi=10.1016/j.cell.2012.03.042; citation_id=CR1\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Science; citation_title=Spermidine in health and disease; citation_author=F Madeo, T Eisenberg, F Pietrocola, G Kroemer; citation_volume=359; citation_publication_date=2018; citation_doi=10.1126/science.aan2788; citation_id=CR2\"/>\n <meta name=\"citation_reference\" content=\"Ca&#241;eque, T. et al. Activation of lysosomal iron triggers ferroptosis in cancer. Nature 642, 492&#8211;500 (2025).\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Cell Biol.; citation_title=A guideline on the molecular ecosystem regulating ferroptosis; citation_author=E Dai; citation_volume=26; citation_publication_date=2024; citation_pages=1447-1457; citation_doi=10.1038/s41556-024-01360-8; citation_id=CR4\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=J. Hematol. Oncol.; citation_title=Ferroptosis: principles and significance in health and disease; citation_author=F Chen, R Kang, D Tang, J Liu; citation_volume=17; citation_publication_date=2024; citation_pages=41; citation_doi=10.1186/s13045-024-01564-3; citation_id=CR5\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cell; citation_title=Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease; citation_author=BR Stockwell; citation_volume=171; citation_publication_date=2017; citation_pages=273-285; citation_doi=10.1016/j.cell.2017.09.021; citation_id=CR6\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Science; citation_title=Ferroptosis-disease perils and therapeutic promise; citation_author=AR Brown, T Hirschhorn, BR Stockwell; citation_volume=386; citation_publication_date=2024; citation_pages=848-849; citation_doi=10.1126/science.adn7030; citation_id=CR7\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cell; citation_title=Regulation of ferroptotic cancer cell death by GPX4; citation_author=WS Yang; citation_volume=156; citation_publication_date=2014; citation_pages=317-331; citation_doi=10.1016/j.cell.2013.12.010; citation_id=CR8\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=FSP1 is a glutathione-independent ferroptosis suppressor; citation_author=S Doll; citation_volume=575; citation_publication_date=2019; citation_pages=693-698; citation_doi=10.1038/s41586-019-1707-0; citation_id=CR9\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis; citation_author=K Bersuker; citation_volume=575; citation_publication_date=2019; citation_pages=688-692; citation_doi=10.1038/s41586-019-1705-2; citation_id=CR10\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=7-Dehydrocholesterol dictates ferroptosis sensitivity; citation_author=Y Li; citation_volume=626; citation_publication_date=2024; citation_pages=411-418; citation_doi=10.1038/s41586-023-06983-9; citation_id=CR11\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=7-Dehydrocholesterol is an endogenous suppressor of ferroptosis; citation_author=FP Freitas; citation_volume=626; citation_publication_date=2024; citation_pages=401-410; citation_doi=10.1038/s41586-023-06878-9; citation_id=CR12\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cell; citation_title=Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine; citation_author=B Fakler; citation_volume=80; citation_publication_date=1995; citation_pages=149-154; citation_doi=10.1016/0092-8674(95)90459-X; citation_id=CR13\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Science; citation_title=Spermine and spermidine as gating molecules for inward rectifier K+ channels; citation_author=E Ficker, M Taglialatela, BA Wible, CM Henley, AM Brown; citation_volume=266; citation_publication_date=1994; citation_pages=1068-1072; citation_doi=10.1126/science.7973666; citation_id=CR14\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=Polyamine-dependent metabolic shielding regulates alternative splicing; citation_author=A Zabala-Letona; citation_volume=651; citation_publication_date=2026; citation_pages=819-828; citation_doi=10.1038/s41586-025-09965-1; citation_id=CR15\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Cell Biol.; citation_title=Spermidine is essential for fasting-mediated autophagy and longevity; citation_author=SJ Hofer; citation_volume=26; citation_publication_date=2024; citation_pages=1571-1584; citation_doi=10.1038/s41556-024-01468-x; citation_id=CR16\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Med.; citation_title=Cardioprotection and lifespan extension by the natural polyamine spermidine; citation_author=T Eisenberg; citation_volume=22; citation_publication_date=2016; citation_pages=1428-1438; citation_doi=10.1038/nm.4222; citation_id=CR17\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Cell Biol.; citation_title=Induction of autophagy by spermidine promotes longevity; citation_author=T Eisenberg; citation_volume=11; citation_publication_date=2009; citation_pages=1305-1314; citation_doi=10.1038/ncb1975; citation_id=CR18\"/>\n <meta name=\"citation_reference\" content=\"Kang, R., Liu, J., Wang, J., Kroemer, G. &amp; Tang, D. Translating ferroptosis into oncology: challenges, opportunities and future directions. Nat. Rev. Clin. Oncol. \n https://doi.org/10.1038/s41571-026-01128-z\n \n (2026).\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cancer Cell; citation_title=mTORC2 promotes tumorigenesis via lipid synthesis; citation_author=Y Guri; citation_volume=32; citation_publication_date=2017; citation_pages=807-823; citation_doi=10.1016/j.ccell.2017.11.011; citation_id=CR20\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Cancer Cell; citation_title=Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4; citation_author=DH Dapito; citation_volume=21; citation_publication_date=2012; citation_pages=504-516; citation_doi=10.1016/j.ccr.2012.02.007; citation_id=CR21\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Rev. Cancer; citation_title=The immunological and metabolic landscape in primary and metastatic liver cancer; citation_author=X Li; citation_volume=21; citation_publication_date=2021; citation_pages=541-557; citation_doi=10.1038/s41568-021-00383-9; citation_id=CR22\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Rev. Cancer; citation_title=Polyamine metabolism and cancer: treatments, challenges and opportunities; citation_author=RA Casero, T Murray Stewart, AE Pegg; citation_volume=18; citation_publication_date=2018; citation_pages=681-695; citation_doi=10.1038/s41568-018-0050-3; citation_id=CR23\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nature; citation_title=mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer; citation_author=A Zabala-Letona; citation_volume=547; citation_publication_date=2017; citation_pages=109-113; citation_doi=10.1038/nature22964; citation_id=CR24\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Commun.; citation_title=Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer; citation_author=G Bi; citation_volume=15; citation_publication_date=2024; citation_doi=10.1038/s41467-024-46776-w; citation_id=CR25\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Nat. Commun.; citation_title=Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics; citation_author=H Bae; citation_volume=16; citation_publication_date=2025; citation_doi=10.1038/s41467-025-60226-1; citation_id=CR26\"/>\n <meta name=\"citation_reference\" content=\"citation_journal_title=Free Radic. Biol. 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